PMID- 17378894
OWN - NLM
STAT- MEDLINE
DCOM- 20070927
LR  - 20070323
IS  - 0902-4441 (Print)
IS  - 0902-4441 (Linking)
VI  - 78
IP  - 4
DP  - 2007 Apr
TI  - Low IgE monoclonal gammopathy level in serum highlights 20-yr survival in a case 
      of IgE multiple myeloma.
PG  - 353-7
AB  - This report describes the diagnosis, follow-up, and problems measuring serum 
      immunoglobulin E (IgE) levels in a case of IgE myeloma with 20-yr survival. Serum 
      and urine protein electrophoresis, immunofixation, and the N Latex IgE test were 
      used to characterize the monoclonal proteins. The diagnosis of multiple myeloma 
      in a 56-yr-old man was based on 5.4 g/24 h of monoclonal free lambda chain in 
      urine and bone marrow findings of 23.5% plasma cells (19% mature and 4.5% 
      atypical). IgE lambda monoclonal protein in serum measured 506,000 microg/L (210 
      833 IU/mL). The lack of other clinical findings of multiple myeloma places this 
      case in the category of 'smoldering or indolent myeloma'. Measurement of serum 
      IgE levels was complicated by the need to predilute serum to avoid antigen 
      excess. Following chemotherapy, the patient went into clinical remission, 
      eventually dying of complications of emphysema. This case expands the recognized 
      clinical spectrum of IgE multiple myeloma.
FAU - Hayes, Michael J
AU  - Hayes MJ
AD  - Department of Pathology, The University of Michigan, Ann Arbor, MI, USA.
FAU - Carey, John L
AU  - Carey JL
FAU - Krauss, John C
AU  - Krauss JC
FAU - Hedstrom, Deborah L
AU  - Hedstrom DL
FAU - Gulbranson, Ronald L
AU  - Gulbranson RL
FAU - Keren, David F
AU  - Keren DF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Eur J Haematol
JT  - European journal of haematology
JID - 8703985
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Blood Protein Electrophoresis/methods
MH  - Emphysema/complications
MH  - Fatal Outcome
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypergammaglobulinemia/*blood/urine
MH  - Immunoglobulin E/*blood/urine
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/*blood/diagnosis/drug therapy
MH  - Paraproteinemias/*blood/*diagnosis/urine
MH  - Time
EDAT- 2007/03/24 09:00
MHDA- 2007/09/28 09:00
CRDT- 2007/03/24 09:00
PHST- 2007/03/24 09:00 [pubmed]
PHST- 2007/09/28 09:00 [medline]
PHST- 2007/03/24 09:00 [entrez]
AID - EJH825 [pii]
AID - 10.1111/j.1600-0609.2007.00825.x [doi]
PST - ppublish
SO  - Eur J Haematol. 2007 Apr;78(4):353-7. doi: 10.1111/j.1600-0609.2007.00825.x.