PMID- 17379440
OWN - NLM
STAT- MEDLINE
DCOM- 20070806
LR  - 20220318
IS  - 0360-3016 (Print)
IS  - 0360-3016 (Linking)
VI  - 68
IP  - 4
DP  - 2007 Jul 15
TI  - Three-dimensional conformal simultaneously integrated boost technique for 
      breast-conserving radiotherapy.
PG  - 1018-23
AB  - PURPOSE: To compare the target coverage and normal tissue dose with the 
      simultaneously integrated boost (SIB) and the sequential boost technique in 
      breast cancer, and to evaluate the incidence of acute skin toxicity in patients 
      treated with the SIB technique. METHODS AND MATERIALS: Thirty patients with 
      early-stage left-sided breast cancer underwent breast-conserving radiotherapy 
      using the SIB technique. The breast and boost planning target volumes (PTVs) were 
      treated simultaneously (i.e., for each fraction, the breast and boost PTVs 
      received 1.81 Gy and 2.3 Gy, respectively). Three-dimensional conformal beams 
      with wedges were shaped and weighted using forward planning. Dose-volume 
      histograms of the PTVs and organs at risk with the SIB technique, 28 x (1.81 + 
      0.49 Gy), were compared with those for the sequential boost technique, 25 x 2 Gy 
      + 8 x 2 Gy. Acute skin toxicity was evaluated for 90 patients treated with the 
      SIB technique according to Common Terminology Criteria for Adverse Events, 
      version 3.0. RESULTS: PTV coverage was adequate with both techniques. With SIB, 
      more efficiently shaped boost beams resulted in smaller irradiated volumes. The 
      mean volume receiving > or =107% of the breast dose was reduced by 20%, the mean 
      volume outside the boost PTV receiving > or =95% of the boost dose was reduced by 
      54%, and the mean heart and lung dose were reduced by 10%. Of the evaluated 
      patients, 32.2% had Grade 2 or worse toxicity. CONCLUSION: The SIB technique is 
      proposed for standard use in breast-conserving radiotherapy because of its 
      dose-limiting capabilities, easy implementation, reduced number of treatment 
      fractions, and relatively low incidence of acute skin toxicity.
FAU - van der Laan, Hans Paul
AU  - van der Laan HP
AD  - Department of Radiation Oncology, University Medical Center Groningen/University 
      of Groningen, 9700 RB Groningen, The Netherlands. h.p.van.der.laan@rt.umcg.nl
FAU - Dolsma, Wil V
AU  - Dolsma WV
FAU - Maduro, John H
AU  - Maduro JH
FAU - Korevaar, Erik W
AU  - Korevaar EW
FAU - Hollander, Miranda
AU  - Hollander M
FAU - Langendijk, Johannes A
AU  - Langendijk JA
LA  - eng
PT  - Journal Article
DEP - 20070326
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
SB  - IM
CIN - Future Oncol. 2007 Oct;3(5):509-13. PMID: 17927516
MH  - Breast/radiation effects
MH  - Breast Neoplasms/*radiotherapy
MH  - Dose Fractionation, Radiation
MH  - Female
MH  - Heart/radiation effects
MH  - Humans
MH  - Lung/radiation effects
MH  - Radiodermatitis/*etiology
MH  - Radiotherapy, Conformal/*methods
EDAT- 2007/03/24 09:00
MHDA- 2007/08/07 09:00
CRDT- 2007/03/24 09:00
PHST- 2006/12/12 00:00 [received]
PHST- 2007/01/08 00:00 [revised]
PHST- 2007/01/11 00:00 [accepted]
PHST- 2007/03/24 09:00 [pubmed]
PHST- 2007/08/07 09:00 [medline]
PHST- 2007/03/24 09:00 [entrez]
AID - S0360-3016(07)00200-3 [pii]
AID - 10.1016/j.ijrobp.2007.01.037 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1018-23. doi: 
      10.1016/j.ijrobp.2007.01.037. Epub 2007 Mar 26.