PMID- 17379960
OWN - NLM
STAT- MEDLINE
DCOM- 20071002
LR  - 20221207
IS  - 0918-8959 (Print)
IS  - 0918-8959 (Linking)
VI  - 54
IP  - 2
DP  - 2007 Apr
TI  - Long-term follow-up of patients with multiple endocrine neoplasia type 1.
PG  - 295-302
AB  - Whether early surgical treatment of non-functioning pancreas islet cell tumor 
      (NFPT) provides a favorable quality of life and life expectancy in patients with 
      multiple endocrine neoplasia type 1 (MEN1) remains controversial. We analyzed the 
      long-term clinical courses and surgical outcomes of 14 Japanese patients with 
      MEN1-associated NFPTs. NFPTs smaller than 20 mm in diameter did not show any 
      apparent growth over a long monitoring period. Furthermore, these small NFPTs did 
      not metastasize to regional lymph nodes or the liver. On the other hand, the 
      development of additional NFPTs or metastasis was found in five of six patients 
      with large (35 mm or larger) NFPTs. Among the seven patients who underwent a 
      partial pancreatectomy, six patients developed impaired glucose tolerance or 
      diabetes. The accumulation of more prospective data is needed to clarify the 
      optimal surgical indications for patients with NFPTs, especially among the 
      Japanese population, which has a relatively low insulin secretion potency 
      compared with non-Hispanic white and African-American populations.
FAU - Sakurai, Akihiro
AU  - Sakurai A
AD  - Department of Aging Medicine and Geriatrics, Shinshu University Graduate School 
      of Medicine, Japan.
FAU - Katai, Miyuki
AU  - Katai M
FAU - Yamashita, Koh
AU  - Yamashita K
FAU - Mori, Jun-Ichiro
AU  - Mori J
FAU - Fukushima, Yoshimitsu
AU  - Fukushima Y
FAU - Hashizume, Kiyoshi
AU  - Hashizume K
LA  - eng
PT  - Journal Article
DEP - 20070320
PL  - Japan
TA  - Endocr J
JT  - Endocrine journal
JID - 9313485
SB  - IM
MH  - Adenoma, Islet Cell/diagnostic imaging/*etiology/physiopathology/*surgery
MH  - Adult
MH  - Asian People
MH  - Diabetes Mellitus/etiology
MH  - Disease Progression
MH  - Female
MH  - Follow-Up Studies
MH  - Glucose Intolerance/etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*complications/ethnology
MH  - Neoplasm Metastasis
MH  - Neoplasms, Second Primary/diagnostic imaging
MH  - Pancreas/physiopathology
MH  - Pancreatectomy/adverse effects/methods
MH  - Pancreatic Neoplasms/diagnostic imaging/*etiology/physiopathology/*surgery
MH  - Tomography, X-Ray Computed
EDAT- 2007/03/24 09:00
MHDA- 2007/10/03 09:00
CRDT- 2007/03/24 09:00
PHST- 2007/03/24 09:00 [pubmed]
PHST- 2007/10/03 09:00 [medline]
PHST- 2007/03/24 09:00 [entrez]
AID - JST.JSTAGE/endocrj/K06-147 [pii]
AID - 10.1507/endocrj.k06-147 [doi]
PST - ppublish
SO  - Endocr J. 2007 Apr;54(2):295-302. doi: 10.1507/endocrj.k06-147. Epub 2007 Mar 20.