PMID- 17380223
OWN - NLM
STAT- MEDLINE
DCOM- 20070523
LR  - 20190608
IS  - 0828-282X (Print)
IS  - 1916-7075 (Electronic)
IS  - 0828-282X (Linking)
VI  - 23
IP  - 4
DP  - 2007 Mar 15
TI  - Usefulness of the brain natriuretic peptide to atrial natriuretic peptide ratio 
      in determining the severity of mitral regurgitation.
PG  - 295-300
AB  - BACKGROUND: Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) 
      levels were characterized in subjects with mitral regurgitation (MR). METHODS: 
      Sixty-two cases of moderate or severe chronic MR were studied. The blood levels 
      of neurohormonal factors were stratified by the known MR prognostic factors of 
      New York Heart Association (NYHA) functional class, left ventricular 
      end-diastolic diameters, left ventricular end-systolic diameter (LVDs), ejection 
      fraction (EF), left atrial diameter and presence of atrial fibrillation (AF). 
      RESULTS: ANP levels were higher in NYHA class II and lower in classes I and 
      III/IV (P=0.0206). BNP levels were higher in NYHA class II than class I 
      (P=0.0355). The BNP/ANP ratio was significantly higher in NYHA classes II and 
      III/IV than in class I (P=0.0007). To differentiate between NYHA classes I/II and 
      III/IV, a cut-off BNP/ANP ratio of 2.97 produced a sensitivity of 78% and 
      specificity of 87%. Compared with subjects in sinus rhythm, patients with AF had 
      an enlarged left atrium and lower ANP levels. The BNP/ANP ratio correlated 
      significantly with left atrial diameter, LVDs and EF (r=0.429, P=0.0017; r=0.351, 
      P=0.0117; and r=-0.349, P=0.0122; respectively), and was significantly higher 
      among all the known operative indications for MR tested (LVDs 45 mm or more, EF 
      60% or less, NYHA class II or greater and AF; P=0.0073, P=0.003, P=0.0102 and 
      P=0.0149, respectively). CONCLUSIONS: In chronic MR, levels of ANP and BNP, and 
      the BNP/ANP ratio are potential indicators of disease severity.
FAU - Shimamoto, Ken
AU  - Shimamoto K
AD  - Department of Cardiology, Tokyo Women's Medical University, Aoyama Hospital, 
      Tokyo, Japan.
FAU - Kusumoto, Miyako
AU  - Kusumoto M
FAU - Sakai, Rieko
AU  - Sakai R
FAU - Watanabe, Hirota
AU  - Watanabe H
FAU - Ihara, Syunichi
AU  - Ihara S
FAU - Koike, Natsuka
AU  - Koike N
FAU - Kawana, Masatoshi
AU  - Kawana M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Can J Cardiol
JT  - The Canadian journal of cardiology
JID - 8510280
RN  - 0 (Biomarkers)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Atrial Natriuretic Factor/*blood
MH  - Biomarkers/blood
MH  - Female
MH  - Heart Failure/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Insufficiency/*blood/diagnosis
MH  - Natriuretic Peptide, Brain/*blood
MH  - Predictive Value of Tests
MH  - Research Design
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
PMC - PMC2647887
EDAT- 2007/03/24 09:00
MHDA- 2007/05/24 09:00
PMCR- 2008/03/15
CRDT- 2007/03/24 09:00
PHST- 2007/03/24 09:00 [pubmed]
PHST- 2007/05/24 09:00 [medline]
PHST- 2007/03/24 09:00 [entrez]
PHST- 2008/03/15 00:00 [pmc-release]
AID - S0828-282X(07)70758-4 [pii]
AID - cjc230295 [pii]
AID - 10.1016/s0828-282x(07)70758-4 [doi]
PST - ppublish
SO  - Can J Cardiol. 2007 Mar 15;23(4):295-300. doi: 10.1016/s0828-282x(07)70758-4.