PMID- 17382262
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20071115
IS  - 1521-690X (Print)
IS  - 1521-690X (Linking)
VI  - 21
IP  - 1
DP  - 2007 Mar
TI  - Molecular genetics of neuroendocrine tumors.
PG  - 1-14
AB  - Neuroendocrine tumors can develop either sporadically or in association with 
      familial syndromes such as multiple endocrine neoplasia type 1 (MEN1), multiple 
      endocrine neoplasia type 2 (MEN2) or von Hippel-Lindau (VHL). A variety of 
      genetic approaches has been utilized to dissect the underlying molecular 
      pathogenesis of these distinctive tumors, including genome-wide screens such as 
      comparative genomic hybridization, loss of heterozygosity and DNA microarray 
      analysis as well as targeted investigations into specific tumor suppressor gene 
      and oncogene candidates. The identification of the MEN1 tumor suppressor gene 
      that underlies the MEN1 syndrome has provided important new insights into tumor 
      pathogenesis. In addition, a number of independent approaches has converged on a 
      pivotal role for regulators of the cell cycle. However, our understanding of the 
      molecular biology of these tumors remains far from complete. In this review we 
      highlight some of the key approaches, findings and implications of these genetic 
      studies.
FAU - Duerr, Eva-Maria
AU  - Duerr EM
AD  - Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, 
      Boston, MA 02114, USA.
FAU - Chung, Daniel C
AU  - Chung DC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Best Pract Res Clin Endocrinol Metab
JT  - Best practice & research. Clinical endocrinology & metabolism
JID - 101120682
SB  - IM
MH  - Animals
MH  - Cell Cycle/genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human
MH  - Gene Expression Profiling/methods
MH  - Humans
MH  - Loss of Heterozygosity
MH  - Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/genetics
MH  - Multiple Endocrine Neoplasia Type 2a/genetics
MH  - Neuroendocrine Tumors/*genetics
MH  - Nucleic Acid Hybridization/methods
MH  - Syndrome
MH  - von Hippel-Lindau Disease/genetics
RF  - 88
EDAT- 2007/03/27 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/03/27 09:00
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
AID - S1521-690X(06)00110-2 [pii]
AID - 10.1016/j.beem.2006.12.001 [doi]
PST - ppublish
SO  - Best Pract Res Clin Endocrinol Metab. 2007 Mar;21(1):1-14. doi: 
      10.1016/j.beem.2006.12.001.