PMID- 17382555
OWN - NLM
STAT- MEDLINE
DCOM- 20070618
LR  - 20181201
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 37
IP  - 1
DP  - 2007 Jan
TI  - Specificity of immunomodulator secretion in urinary samples in response to 
      infection by alpha-hemolysin and CNF1 bearing uropathogenic Escherichia coli.
PG  - 22-5
AB  - Escherichia coli are the most common etiological agents of urinary tract 
      infections (UTIs). Uropathogenic E. coli (UPECs) produce specific toxins 
      including the cytotoxic necrotizing factor-1 (CNF1) and the alpha-hemolysin 
      (alpha-Hly). CNF1 triggers, through Rho protein activation, a specific gene 
      response of host cells, which results in the production for instance of 
      interleukin-8 (IL-8), monocyte chemoattractant protein-1 (MCP-1) and the 
      macrophage inflammatory protein-3alpha (MIP-3alpha). The alpha hemolysin 
      alpha-Hly also triggers the production of inflammatory mediators. Cnf1 is always 
      associated with alpha-hly in a pathogenicity island conserved among UPECs. Using 
      two complementary approaches we have investigated whether alpha-hly and cnf1 
      bearing UPECs are associated with a specific type of UTI both in term of 
      pathology and host response. Here we report that UPECs bearing alpha-hly/cnf1 
      have a prevalence of 50% in UPECs isolated from hemorrhagic UTIs, as compared to 
      30% in the overall UPEC population. In addition, we observed that MCP-1, and IL-8 
      to a lower extent, is produced in urine at higher concentrations in UTIs caused 
      by UPECs carrying alpha-hly/cnf1.
FAU - Real, Jean-Michel
AU  - Real JM
AD  - INSERM, U627, Faculte de Medecine, 28 Avenue de Valombrose, F-06107 Nice Cedex 2, 
      France.
FAU - Munro, Patrick
AU  - Munro P
FAU - Buisson-Touati, Caroline
AU  - Buisson-Touati C
FAU - Lemichez, Emmanuel
AU  - Lemichez E
FAU - Boquet, Patrice
AU  - Boquet P
FAU - Landraud, Luce
AU  - Landraud L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070326
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Bacterial Toxins)
RN  - 0 (CCL2 protein, human)
RN  - 0 (CCL20 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL20)
RN  - 0 (Chemokines, CC)
RN  - 0 (Escherichia coli Proteins)
RN  - 0 (Hemolysin Proteins)
RN  - 0 (Hlya protein, E coli)
RN  - 0 (Interleukin-8)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 106803-33-2 (cytotoxic necrotizing factor type 1)
SB  - IM
MH  - Bacterial Toxins/genetics/*metabolism
MH  - Chemokine CCL2/metabolism/*urine
MH  - Chemokine CCL20
MH  - Chemokines, CC/metabolism/*urine
MH  - Escherichia coli/*immunology/*pathogenicity
MH  - Escherichia coli Infections/genetics/immunology/*microbiology/*urine
MH  - Escherichia coli Proteins/genetics/*metabolism
MH  - Health
MH  - Hemolysin Proteins/*metabolism
MH  - Hemorrhage/genetics/microbiology/pathology
MH  - Humans
MH  - Interleukin-8/metabolism/*urine
MH  - Macrophage Inflammatory Proteins/metabolism/*urine
EDAT- 2007/03/27 09:00
MHDA- 2007/06/19 09:00
CRDT- 2007/03/27 09:00
PHST- 2006/07/11 00:00 [received]
PHST- 2006/12/22 00:00 [revised]
PHST- 2007/02/07 00:00 [accepted]
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/06/19 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
AID - S1043-4666(07)00024-5 [pii]
AID - 10.1016/j.cyto.2007.02.016 [doi]
PST - ppublish
SO  - Cytokine. 2007 Jan;37(1):22-5. doi: 10.1016/j.cyto.2007.02.016. Epub 2007 Mar 26.