PMID- 17382888
OWN - NLM
STAT- MEDLINE
DCOM- 20070508
LR  - 20191210
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 128
IP  - 6
DP  - 2007 Mar 23
TI  - Proteolytic degradation of SCOP in the hippocampus contributes to activation of 
      MAP kinase and memory.
PG  - 1219-29
AB  - Because activation of ERK1/2 MAP kinase (MAPK) is critical for 
      hippocampus-dependent memory, there is considerable interest in mechanisms for 
      regulation of MAPK during memory formation. Here we report that MAPK and 
      CREB-mediated transcription are negatively regulated by SCOP (suprachiasmatic 
      nucleus [SCN] circadian oscillatory protein) and that SCOP is proteolyzed by 
      calpain when hippocampal neurons are stimulated by brain-derived neurotrophic 
      factor (BDNF), KCl depolarization, or NMDA. Moreover, training for novel object 
      memory decreases SCOP in the hippocampus. To determine if hippocampus-dependent 
      memory is influenced by SCOP in vivo, we generated a transgenic mouse strain for 
      the inducible overexpression of SCOP in the forebrain. Overexpression of SCOP 
      completely blocked memory for novel objects. We conclude that degradation of SCOP 
      by calpain contributes to activation of MAPK during memory formation.
FAU - Shimizu, Kimiko
AU  - Shimizu K
AD  - Department of Pharmacology, The University of Washington, Seattle, WA 98195, USA.
FAU - Phan, Trongha
AU  - Phan T
FAU - Mansuy, Isabelle M
AU  - Mansuy IM
FAU - Storm, Daniel R
AU  - Storm DR
LA  - eng
GR  - R01 MH073601/MH/NIMH NIH HHS/United States
GR  - R01 NS020498/NS/NINDS NIH HHS/United States
GR  - NS 20498/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Excitatory Amino Acid Agonists)
RN  - 0 (Nuclear Proteins)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - 660YQ98I10 (Potassium Chloride)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, mouse)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 3.1.3.16 (PHLPP1 protein, mouse)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
RN  - EC 3.4.22.- (Calpain)
RN  - SY7Q814VUP (Calcium)
SB  - IM
CIN - Cell. 2007 Mar 23;128(6):1029-30. PMID: 17382874
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - CREB-Binding Protein/metabolism
MH  - Calcium/metabolism
MH  - Calpain/antagonists & inhibitors/*metabolism
MH  - Cell Culture Techniques
MH  - Excitatory Amino Acid Agonists/pharmacology
MH  - Hippocampus/cytology/*metabolism
MH  - Humans
MH  - MAP Kinase Signaling System
MH  - *Memory
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Transgenic
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - N-Methylaspartate/pharmacology
MH  - Neurons/metabolism
MH  - Nuclear Proteins/*metabolism
MH  - Phosphoprotein Phosphatases/*metabolism
MH  - Potassium Chloride/pharmacology
MH  - Rats
MH  - Regulatory Elements, Transcriptional
MH  - Transcription, Genetic
PMC - PMC1899088
MID - NIHMS20467
EDAT- 2007/03/27 09:00
MHDA- 2007/05/09 09:00
PMCR- 2008/03/23
CRDT- 2007/03/27 09:00
PHST- 2006/04/04 00:00 [received]
PHST- 2006/11/28 00:00 [revised]
PHST- 2006/12/29 00:00 [accepted]
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/05/09 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
PHST- 2008/03/23 00:00 [pmc-release]
AID - S0092-8674(07)00203-6 [pii]
AID - 10.1016/j.cell.2006.12.047 [doi]
PST - ppublish
SO  - Cell. 2007 Mar 23;128(6):1219-29. doi: 10.1016/j.cell.2006.12.047.