PMID- 17383147
OWN - NLM
STAT- MEDLINE
DCOM- 20070618
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 36
IP  - 5 Pt 1
DP  - 2007 May
TI  - Familial occurrence of painful subacute thyroiditis associated with human 
      leukocyte antigen-B35.
PG  - 808-9
AB  - INTRODUCTION: Subacute thyroiditis (SAT) is a spontaneously remitting 
      inflammatory disorder of the thyroid that is presumed to be virally induced in 
      genetically predisposed individuals. A strong association has been suggested 
      between human leukocyte antigen (HLA)-B35 and patients who developed SAT. 
      However, familial occurrence of SAT associated with HLA-B35 is reported only 
      rarely. CASE-REPORTS: We report three sibs, (two brothers and one sister) living 
      in the same Lebanese town, who developed SAT during an 18-month-period. All 
      tested positive for HLA-B35. DISCUSSION: The family described here represents the 
      first Third World third familial report of SAT associated with HLA-B35. It 
      highlights the probably underestimated importance of genetic predisposition to 
      SAT in families.
FAU - Zein, Emile F
AU  - Zein EF
AD  - Internal medicine and infectious diseases department, Saint-Joseph Hospital and 
      Medical Center, Dora, Lebanon. dremilezein2000@yahoo.com
FAU - Karaa, Souheil E
AU  - Karaa SE
FAU - Megarbane, Andre
AU  - Megarbane A
LA  - eng
PT  - Journal Article
DEP - 20070323
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (HLA-B35 Antigen)
RN  - 90Y4QC304K (Ketoprofen)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - VB0R961HZT (Prednisone)
SB  - IM
MH  - Administration, Oral
MH  - Adrenergic beta-Antagonists/administration & dosage/therapeutic use
MH  - Adult
MH  - Anti-Inflammatory Agents/administration & dosage/therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/administration & dosage/therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-B35 Antigen/*genetics
MH  - Humans
MH  - Ketoprofen/administration & dosage/therapeutic use
MH  - Male
MH  - Prednisone/administration & dosage/therapeutic use
MH  - Propranolol/administration & dosage/therapeutic use
MH  - Thyroiditis, Subacute/diagnosis/*drug therapy/*genetics/immunology
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2007/03/27 09:00
MHDA- 2007/06/19 09:00
CRDT- 2007/03/27 09:00
PHST- 2006/06/29 00:00 [received]
PHST- 2006/11/06 00:00 [accepted]
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/06/19 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
AID - S0755-4982(07)00172-8 [pii]
AID - 10.1016/j.lpm.2007.02.011 [doi]
PST - ppublish
SO  - Presse Med. 2007 May;36(5 Pt 1):808-9. doi: 10.1016/j.lpm.2007.02.011. Epub 2007 
      Mar 23.