PMID- 17383209
OWN - NLM
STAT- MEDLINE
DCOM- 20071018
LR  - 20220408
IS  - 1096-6374 (Print)
IS  - 1096-6374 (Linking)
VI  - 17
IP  - 4
DP  - 2007 Aug
TI  - NT-proBNP, IGF-I and survival in patients with chronic heart failure.
PG  - 288-96
AB  - OBJECTIVE: Growth hormone (GH) resistance with a reduction of insulin-like growth 
      factor-I (IGF-I) serum concentrations seems to be implicated in the catabolic 
      process associated with chronic heart failure (CHF). However, data concerning the 
      prognostic value of these alterations in CHF patients without cachexia are scant. 
      In this study, we aimed to determine in CHF patients the prognostic value of 
      IGF-I/GH ratio and its relationships with N-terminal brain natriuretic peptide 
      (NT-proBNP), a known marker of prognosis in these patients. DESIGN: We enrolled 
      82 non-cachectic patients, mean age 61+/-13 years, with ejection fraction <40% 
      and predischarge New York Heart Association (NYHA) functional classes II-IV. All 
      patients underwent clinical examination, two-dimensional echocardiography and 
      NT-proBNP, GH and IGF-I measurement with log IGF-I/GH ratio calculation. 
      Mortality and clinical status was documented at follow-up (18.4+/-8.1 months). 
      RESULTS: During follow-up 17 patients died of cardiac causes. Non-survivors were 
      at baseline in higher NYHA class (P<0.05) and showed higher values of NT-proBNP 
      (P<0.001) than survivors; differently IGF-I, and log IGF-I/GH ratio were lower 
      (P<0.05). At Cox multivariate analysis, NT-proBNP (P<0.001) and IGF-I/GH ratio 
      (P<0.05) were independent predictors of death. CONCLUSIONS: High NT-proBNP levels 
      and low IGH-I/GH ratio may be useful to stratify CHF patients at higher risk of 
      cardiac death.
FAU - Petretta, Mario
AU  - Petretta M
AD  - Department of Internal Medicine, Cardiology, Heart and Immunological Sciences, 
      Section of Internal Medicine, University of Naples Federico II, Italy.
FAU - Colao, Annamaria
AU  - Colao A
FAU - Sardu, Celestino
AU  - Sardu C
FAU - Scopacasa, Franco
AU  - Scopacasa F
FAU - Marzullo, Paolo
AU  - Marzullo P
FAU - Pivonello, Rosario
AU  - Pivonello R
FAU - Fontanella, Luca
AU  - Fontanella L
FAU - de Caterina, Maurizio
AU  - de Caterina M
FAU - de Simone, Adriano
AU  - de Simone A
FAU - Bonaduce, Domenico
AU  - Bonaduce D
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20070323
PL  - Scotland
TA  - Growth Horm IGF Res
JT  - Growth hormone & IGF research : official journal of the Growth Hormone Research 
      Society and the International IGF Research Society
JID - 9814320
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*blood/complications/diagnosis/*mortality
MH  - Humans
MH  - Insulin-Like Growth Factor I/*analysis
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Risk Factors
MH  - Wasting Syndrome/diagnosis/etiology
EDAT- 2007/03/27 09:00
MHDA- 2007/10/19 09:00
CRDT- 2007/03/27 09:00
PHST- 2006/11/30 00:00 [received]
PHST- 2007/01/31 00:00 [revised]
PHST- 2007/01/31 00:00 [accepted]
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/10/19 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
AID - S1096-6374(07)00025-1 [pii]
AID - 10.1016/j.ghir.2007.01.020 [doi]
PST - ppublish
SO  - Growth Horm IGF Res. 2007 Aug;17(4):288-96. doi: 10.1016/j.ghir.2007.01.020. Epub 
      2007 Mar 23.