PMID- 17383833
OWN - NLM
STAT- MEDLINE
DCOM- 20070912
LR  - 20081121
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 123
IP  - 1-3
DP  - 2007 Jul 20
TI  - Genetic diversity and phylogenetic analysis of glycoprotein 5 of PRRSV isolates 
      in mainland China from 1996 to 2006: coexistence of two NA-subgenotypes with 
      great diversity.
PG  - 43-52
AB  - GP5, the most important neutralizing antigen of porcine reproductive and 
      respiratory syndrome virus (PRRSV), has the highest genetic diversity among 
      isolates. To more fully understand the extent of genetic diversity of PRRSV in 
      China, we analyzed and compared the GP5 sequences of 42 PRRSV isolated from 1996 
      to 2006 in mainland China. We found that all of the Chinese isolates examined 
      belong to the North American (NA) type. Among them two highly diverse subgroups 
      were clearly demarcated on the NA-genotype phylogenetic tree. All the subgroup 1 
      isolates were found to be high variable in the primary neutralizing epitope and 
      the viruses were geographically restricted to regions in southeast China. The 
      subgroup 2 isolates shared a high identity with MLV vaccine and its parent virus 
      VR-2332. These results may contribute to the knowledge of PRRSV epidemiology in 
      China, and may help to explain the low efficiency of MLV or killed CH-1a vaccine 
      to protect the subgroup 1 virus infected pigs, and the great genetic diversity 
      should be taken into consideration for control and preventive measures.
FAU - An, Tong-qing
AU  - An TQ
AD  - National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research 
      Institute, Chinese Academy of Agricultural Sciences, 427 Maduan Street, Harbin 
      150001, PR China.
FAU - Zhou, Yan-jun
AU  - Zhou YJ
FAU - Liu, Guang-qing
AU  - Liu GQ
FAU - Tian, Zhi-jun
AU  - Tian ZJ
FAU - Li, Jun
AU  - Li J
FAU - Qiu, Hua-ji
AU  - Qiu HJ
FAU - Tong, Guang-zhi
AU  - Tong GZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070228
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (Epitopes)
RN  - 0 (Glycoproteins)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - China/epidemiology
MH  - Epitopes/chemistry
MH  - *Genetic Variation
MH  - Genotype
MH  - Glycoproteins/chemistry/genetics
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Phylogeny
MH  - Porcine Reproductive and Respiratory Syndrome/*epidemiology/*virology
MH  - Porcine respiratory and reproductive syndrome virus/*classification/*genetics
MH  - Swine/virology
MH  - Time Factors
MH  - Viral Proteins/chemistry/genetics
EDAT- 2007/03/27 09:00
MHDA- 2007/09/13 09:00
CRDT- 2007/03/27 09:00
PHST- 2006/11/17 00:00 [received]
PHST- 2007/02/11 00:00 [revised]
PHST- 2007/02/22 00:00 [accepted]
PHST- 2007/03/27 09:00 [pubmed]
PHST- 2007/09/13 09:00 [medline]
PHST- 2007/03/27 09:00 [entrez]
AID - S0378-1135(07)00109-5 [pii]
AID - 10.1016/j.vetmic.2007.02.025 [doi]
PST - ppublish
SO  - Vet Microbiol. 2007 Jul 20;123(1-3):43-52. doi: 10.1016/j.vetmic.2007.02.025. 
      Epub 2007 Feb 28.