PMID- 17385415
OWN - NLM
STAT- MEDLINE
DCOM- 20070412
LR  - 20080215
IS  - 0564-3783 (Print)
IS  - 0564-3783 (Linking)
VI  - 40
IP  - 5
DP  - 2006 Sep-Oct
TI  - Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted 
      fetus.
PG  - 28-30
AB  - We report on a case of chimerism and multiple abnormalities of chromosomes 21, 
      Xand Yin spontaneous abortion specimen. To the best our knowledge the present 
      case is the first documented chimera in a spontaneously aborted fetus. The 
      application of interphase fluorescence in situ hybridization (FISH) using 
      chromosome enumeration and site-specific DNA probes showed trisomy X in 92 nuclei 
      (23 %), tetrasomy X in 100 nuclei (25 %), pentasomy of chromosome X in 40 nuclei 
      (10 %), XXY in 36 nuclei (9 %), XXXXXXYY in 12 nuclei (3 %), XXXXXYYYYY in 8 
      nuclei (2 %), trisomy 21 and female chromosome complement in 40 nuclei (10 %), 
      normal female chromosome complement in 72 nuclei (18 %) out of 400 nuclei scored. 
      Our experience indicates that the frequency of chimerism coupled with multiple 
      chromosome abnormalities should be no less than 1 : 400 among spontaneous 
      abortions. The difficulties of chimerism identification in fetal tissues are 
      discussed.
FAU - Vorsanova, S G
AU  - Vorsanova SG
AD  - Institute of Pediatrics and Children Surgery, Roszdrav, Moscow, Russia.
FAU - Iourov, I Y
AU  - Iourov IY
FAU - Demidova, I A
AU  - Demidova IA
FAU - Kirillova, E A
AU  - Kirillova EA
FAU - Soloviev, I V
AU  - Soloviev IV
FAU - Yurov, Y B
AU  - Yurov YB
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ukraine
TA  - Tsitol Genet
JT  - TSitologiia i genetika
JID - 0101671
RN  - 0 (DNA Probes)
SB  - IM
MH  - Aborted Fetus
MH  - Abortion, Spontaneous/*genetics
MH  - Adult
MH  - *Chimerism
MH  - *Chromosomes, Human, Pair 21
MH  - *Chromosomes, Human, X
MH  - *Chromosomes, Human, Y
MH  - DNA Probes
MH  - Down Syndrome/embryology/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - *Mosaicism
MH  - Pregnancy
EDAT- 2007/03/28 09:00
MHDA- 2007/04/14 09:00
CRDT- 2007/03/28 09:00
PHST- 2007/03/28 09:00 [pubmed]
PHST- 2007/04/14 09:00 [medline]
PHST- 2007/03/28 09:00 [entrez]
PST - ppublish
SO  - Tsitol Genet. 2006 Sep-Oct;40(5):28-30.