PMID- 17388104
OWN - NLM
STAT- MEDLINE
DCOM- 20070426
LR  - 20180815
IS  - 1109-9666 (Print)
IS  - 1109-9666 (Linking)
VI  - 48
IP  - 1
DP  - 2007 Jan-Feb
TI  - Time course of C-reactive protein, tumour necrosis factor-alpha and monocyte 
      chemoattractant protein-1 following the surgical treatment of patients with 
      aortic valve stenosis.
PG  - 5-14
AB  - INTRODUCTION: Patients with aortic valve stenosis show elevated levels of 
      inflammatory markers in peripheral blood. The aim of this study was to 
      investigate the time course of changes in these markers and to look for 
      sex-related changes in their biological behaviour following aortic valve 
      replacement. METHODS: We studied 52 patients (32 men, 20 women) who underwent 
      aortic valve replacement and had no concomitant coronary artery disease. Men and 
      women did not differ significantly with respect to age, body surface area, or 
      body mass index. Levels of high sensitivity C-reactive protein (hsCRP), tumour 
      necrosis factor-alpha (TNF-alpha) and monocyte chemoattractant protein-1 (MCP-1) 
      were measured from venous blood samples taken before, and 10 days, 3 months and 6 
      months after aortic valve replacement. RESULTS: Baseline hsCRP levels were 5.34 
      +/- 5.71 mg/dl and 7.64 +/- 7.46 mg/dl for men and women, respectively. Levels 
      increased significantly at 10 d (49.11 +/- 32.15 and 51.63 +/- 34.3 mg/dl, p < 
      0.001), then reduced at 3 m (5.85 +/- 5.04 and 8.49 +/- 7.69 mg/dl, p < 0.001) 
      and 6 m (3.41 +/- 0.83 and 7.84 +/- 7.32 mg/dl, p < 0.001). Women had higher 
      levels than men at 6 m (p = 0.027). Levels of TNF-alpha reduced progressively, 
      from 212.4 +/- 119.5 and 255.7 +/- 171.3 pg/ml at baseline, to 121.6 +/- 47.7 and 
      150.0 +/- 33.5 pg/ml at 10 d, 134.7 +/- 25.3 and 138.6 +/- 30.9 at 3 m, and 48.7 
      +/- 8.8 and 44.9 +/- 10.5 pg/ml at 6 m (p < 0.001). MCP-1 levels also reduced 
      progressively, from 157 +/- 64.8 and 145.6 +/- 13.4 pg/ml at baseline, to 128.6 
      +/- 18.8 and 122.7 +/- 10.3 pg/ml at 10 d, 49.0 +/- 12.4 and 56.6 +/- 11.5 pg/ml 
      at 3 m, and 29.1 +/- 6.4 and 30.6 +/- 7.3 pg/ml at 6 m (p < 0.001). The time 
      course of the changes in these indexes was identical for men and women, except 
      that 6 m hsCRP levels were significantly higher in women. CONCLUSIONS: After 
      aortic valve replacement, hsCRP levels show an early increase followed by a 
      decrease, whereas both TNF-alpha and MCP-1 are reduced progressively. The time 
      course curve is identical in men and women, except that hsCRP levels are higher 
      in women than in men 6 months after aortic valve replacement.
FAU - Kastellanos, Stylianos S
AU  - Kastellanos SS
AD  - Cardiac Surgery Department, Hippokration Hospital, Athens, Greece. 
      castel@otenet.gr
FAU - Toumpoulis, Ioannis K
AU  - Toumpoulis IK
FAU - Aggeli, Constadina
AU  - Aggeli C
FAU - Zezas, Stefanos
AU  - Zezas S
FAU - Chlapoutakis, Emmanouil
AU  - Chlapoutakis E
FAU - Kastellanos, Stamatis
AU  - Kastellanos S
FAU - Stefanadis, Christodoulos I
AU  - Stefanadis CI
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Hellenic J Cardiol
JT  - Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese
JID - 101257381
RN  - 0 (Chemokine CCL2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Aortic Valve Stenosis/*blood/*surgery
MH  - C-Reactive Protein/*analysis
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Heart Valve Prosthesis Implantation
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Sex Factors
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2007/03/29 09:00
MHDA- 2007/04/27 09:00
CRDT- 2007/03/29 09:00
PHST- 2007/03/29 09:00 [pubmed]
PHST- 2007/04/27 09:00 [medline]
PHST- 2007/03/29 09:00 [entrez]
PST - ppublish
SO  - Hellenic J Cardiol. 2007 Jan-Feb;48(1):5-14.