PMID- 17388766
OWN - NLM
STAT- MEDLINE
DCOM- 20070503
LR  - 20221207
IS  - 1075-5535 (Print)
IS  - 1075-5535 (Linking)
VI  - 13
IP  - 2
DP  - 2007 Mar
TI  - HLA class II polymorphisms associated with the physiologic characteristics 
      defined by Traditional Chinese Medicine: linking modern genetics with an ancient 
      medicine.
PG  - 231-9
AB  - OBJECTIVES: The aim of this study was to test whether human leukocyte antigen 
      (HLA) polymorphism contributes to the physical constitutions classified in 
      Traditional Chinese Medicine (TCM). DESIGN: Seven hundred six (706) individuals 
      of the Han ethnic group inhabiting South China were classified into 7 TCM 
      constitution groups, according to the criteria described in Theories of Physical 
      Constitutions of Traditional Chinese Medicine, and the distributions of HLA-DRB1, 
      DPB1, and DQB1 were investigated using the polymerase chain 
      reaction-sequencing-based typing method. RESULTS: The allele frequencies of 
      DPB1*0501 in the Yin-deficiency group, DRB1*09012 in the Phlegm-wetness group, 
      and DQB1*03032 in the Qi-deficiency and Phlegm-wetness groups were significantly 
      different from that of the corresponding alleles in the Normality constitution, 
      suggesting those alleles might be group-specific alleles and thus related to a 
      particular constitution. Based on our analysis of serological groups of HLA, the 
      associations of DR*04 with the Blood-stasis group and DQ*09 with the 
      Qi-deficiency and Phlegm-wetness groups were observed. CONCLUSIONS: This was the 
      first study to systematically investigate the relationship between HLA and TCM 
      constitution using a high-resolution typing technique. The results suggested a 
      genetic basis for the classification of physical constitution in TCM. This study 
      laid the foundation, for the first time ever, toward gaining insight into the 
      theory of traditional medicine using modern biological approaches.
FAU - Chen, Shangwu
AU  - Chen S
AD  - State Key Laboratory for Biocontrol, Guangzhou Key Laboratory of Pharmaceutical 
      Functional Genes, Department of Biochemistry, College of Life Sciences, Sun 
      Yat-sen (Zhongshan) University, Guangzhou, People's Republic of China.
FAU - Lv, Fengjuan
AU  - Lv F
FAU - Gao, Jie
AU  - Gao J
FAU - Lin, Jianghai
AU  - Lin J
FAU - Liu, Zehuan
AU  - Liu Z
FAU - Fu, Yonggui
AU  - Fu Y
FAU - Liu, Yin
AU  - Liu Y
FAU - Lin, Bin
AU  - Lin B
FAU - Xie, Yi
AU  - Xie Y
FAU - Ren, Xiangpeng
AU  - Ren X
FAU - Xu, Yunping
AU  - Xu Y
FAU - Fan, Xinlan
AU  - Fan X
FAU - Xu, Anlong
AU  - Xu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Altern Complement Med
JT  - Journal of alternative and complementary medicine (New York, N.Y.)
JID - 9508124
RN  - 0 (HLA Antigens)
SB  - IM
CIN - J Altern Complement Med. 2007 Mar;13(2):183-4. PMID: 17388756
CIN - J Altern Complement Med. 2007 May;13(4):401-2. PMID: 17532731
MH  - Adult
MH  - Asia, Southeastern
MH  - Asian People/genetics
MH  - Female
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - *Polymorphism, Genetic
MH  - *Qi
MH  - *Yin-Yang
EDAT- 2007/03/29 09:00
MHDA- 2007/05/04 09:00
CRDT- 2007/03/29 09:00
PHST- 2007/03/29 09:00 [pubmed]
PHST- 2007/05/04 09:00 [medline]
PHST- 2007/03/29 09:00 [entrez]
AID - 10.1089/acm.2006.6126 [doi]
PST - ppublish
SO  - J Altern Complement Med. 2007 Mar;13(2):231-9. doi: 10.1089/acm.2006.6126.