PMID- 17388988
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 14
IP  - 4
DP  - 2007 Apr
TI  - Clinical and demographical characteristics of primary progressive multiple 
      sclerosis in Isfahan, Iran.
PG  - 403-7
AB  - Primary progressive multiple sclerosis (PPMS) is an uncommon form of multiple 
      sclerosis (MS) in which the course of disease is progressive from onset. In a 
      retrospective study amongst 1606 MS patients registered in Isfahan MS Society 
      (IMSS) from April 2003 to 31 December 2005, 92 PPMS cases were identified. That 
      means, the frequency of PPMS amongst all included MS patients would be 5.7% (95% 
      CI: 6.7% and 4.7%). The mean expanded disability status scale (EDSS) for the 
      group was 5.09 +/- 1.3. The commonest mode of presentation was motor disturbance 
      in 55 (59.8%), other modes of presentation were, vertigo in 15 (16.3%), visual 
      problems in 12 (13%), sensory disturbances in six (6.5%), and diplopia in four 
      (4.3%). The current [corrected] existing symptoms were motor problems in all 92 
      (100%), cerebellar symptoms in 46 (50%), and cognitive impairment in only 
      6[corrected](6.5%). Interestingly, two (2%) were affected by poliomyelitis during 
      childhood and presenting symptom in both was limb weakness. Primary progressive 
      form of MS is less common in Persian population and some of the rates observed in 
      PPMS patients differ from those in other regions, these differences may be due to 
      different ethnicity of Persian patients or to geographical differences.
FAU - Maghzi, A H
AU  - Maghzi AH
AD  - Medical School, Isfahan University of Medical Sciences, Isfahan, Iran. 
      maghzi@edc.mui.ac.ir
FAU - Etemadifar, M
AU  - Etemadifar M
FAU - Saadatnia, M
AU  - Saadatnia M
LA  - eng
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
EIN - Eur J Neurol. 2007 Jun;14(6):711
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Age of Onset
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/*epidemiology
MH  - Poliomyelitis/complications
MH  - Retrospective Studies
MH  - Sex Factors
EDAT- 2007/03/29 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/03/29 09:00
PHST- 2007/03/29 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/03/29 09:00 [entrez]
AID - ENE1680 [pii]
AID - 10.1111/j.1468-1331.2007.01680.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2007 Apr;14(4):403-7. doi: 10.1111/j.1468-1331.2007.01680.x.