PMID- 17389012
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 4
DP  - 2007 Apr
TI  - Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute 
      to the low prevalence of multiple sclerosis in Sami.
PG  - 299-304
AB  - This study confirms a low frequency of multiple sclerosis (MS) among Sami. Only 
      12 Sami with a diagnosis of MS were identified in the Norwegian Sami population, 
      which represents a significantly lower prevalence of MS in Sami (30/10(5)) 
      compared with other Norwegians (73-164/10(5)). The clinical characteristics as 
      well as the results of human leukocyte antigen (HLA)-DRB1 and -DQB1 typing of the 
      Sami MS patients are reported, showing that three (27%) of the Sami MS patients 
      carried the MS-associated HLA-DRB1*15-DQB1*06 haplotype. Interestingly, the 
      DRB1*15-DQB1*06 haplotype had a significantly reduced frequency among Sami 
      controls (0.086) compared with non-Sami Norwegian controls (0.163) (P(corrected) 
      = 0.015). The low frequency of the disease-associated DRB1*15-DQB1*06 haplotype 
      in the Sami population may contribute to the low prevalence of MS in Sami, in 
      addition to other yet unidentified genetic and environmental factors.
FAU - Harbo, H F
AU  - Harbo HF
AD  - Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, 
      Oslo, Norway. h.f.harbo@medisin.uio.no
FAU - Utsi, E
AU  - Utsi E
FAU - Lorentzen, A R
AU  - Lorentzen AR
FAU - Kampman, M T
AU  - Kampman MT
FAU - Celius, E G
AU  - Celius EG
FAU - Myhr, K-M
AU  - Myhr KM
FAU - Lie, B A
AU  - Lie BA
FAU - Mellgren, S I
AU  - Mellgren SI
FAU - Thorsby, E
AU  - Thorsby E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*15 antigen)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Adult
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DQ Antigens/*genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - *Haplotypes
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*genetics
MH  - Middle Aged
MH  - Multiple Sclerosis/epidemiology/*ethnology/*genetics
MH  - Norway
MH  - Prevalence
MH  - Risk Factors
EDAT- 2007/03/29 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/03/29 09:00
PHST- 2007/03/29 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/03/29 09:00 [entrez]
AID - TAN803 [pii]
AID - 10.1111/j.1399-0039.2007.00803.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69(4):299-304. doi: 10.1111/j.1399-0039.2007.00803.x.