PMID- 17389014
OWN - NLM
STAT- MEDLINE
DCOM- 20070626
LR  - 20111117
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 69
IP  - 4
DP  - 2007 Apr
TI  - Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.
PG  - 313-7
AB  - Inflammatory bowel disease (IBD), which comprises ulcerative colitis (UC) and 
      Crohn's disease (CD), shows a multifactorial origin, with genetic and 
      environmental factors involved. Although the genetic influence is clear for both 
      diseases, the genetics involved is complex and epistatic interactions with other 
      genes probably exist. The Fc receptor-like 3 gene (FCRL3) maps to the human 
      chromosome 1q21-22 and certain single nucleotide polymorphisms (SNPs) in its 
      promoter have been associated with some autoimmune diseases. Our aim was to study 
      the role of two promoter SNPs of the FCRL3 gene (-169A>G, rs7528684 and -110C>T, 
      rs11264799) in patients with IBD and their interaction with HLA-DRB1 and CARD15 
      in patients with UC and CD, respectively. A case-control study with 311 patients 
      with CD, 324 patients with UC and 497 healthy controls was performed. All the 
      individuals were White Spaniards. No significant associations were found between 
      any FCRL3 SNP and CD or UC, but the stratification in patients with UC by human 
      leukocyte antigen (HLA) showed a significant increase in heterozygosity at the 
      FCRL3 locus, especially -169 AG (AG vs AA+GG, P= 0.0027, odds ratio = 3.6, 95% 
      confidence interval 1.4-2.9), when HLA-DRB1*0103 carrier patients were compared 
      with HLA-DRB1*0103 noncarriers. Our data suggest an epistatic interaction between 
      genes in chromosomes 6p21 and 1q21-22, marked, respectively, by HLA-DRB1*0103 and 
      FCRL3-169 AG.
FAU - Martinez, A
AU  - Martinez A
AD  - Department of Clinical Immunology, Hospital Clinico San Carlos, Madrid, Spain. 
      alfmdoncel@terra.es
FAU - Nunez, C
AU  - Nunez C
FAU - Martin, M C
AU  - Martin MC
FAU - Mendoza, J L
AU  - Mendoza JL
FAU - Taxonera, C
AU  - Taxonera C
FAU - Diaz-Rubio, M
AU  - Diaz-Rubio M
FAU - de la Concha, E G
AU  - de la Concha EG
FAU - Urcelay, E
AU  - Urcelay E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (FCRL3 protein, human)
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (Receptors, Immunologic)
SB  - IM
MH  - Case-Control Studies
MH  - *Epistasis, Genetic
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA Antigens/biosynthesis
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Heterozygote
MH  - Histocompatibility Antigens/*genetics
MH  - Humans
MH  - Inflammatory Bowel Diseases/ethnology/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Receptors, Immunologic/*genetics
MH  - Spain
EDAT- 2007/03/29 09:00
MHDA- 2007/06/27 09:00
CRDT- 2007/03/29 09:00
PHST- 2007/03/29 09:00 [pubmed]
PHST- 2007/06/27 09:00 [medline]
PHST- 2007/03/29 09:00 [entrez]
AID - TAN816 [pii]
AID - 10.1111/j.1399-0039.2007.00816.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2007 Apr;69(4):313-7. doi: 10.1111/j.1399-0039.2007.00816.x.