PMID- 17392112
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20181201
IS  - 0964-7058 (Print)
IS  - 0964-7058 (Linking)
VI  - 16 Suppl 1
DP  - 2007
TI  - Effect of lycopene on the vascular endothelial function and expression of 
      inflammatory agents in hyperhomocysteinemic rats.
PG  - 244-8
AB  - The aim of this study was to investigate the effect of lycopene on the vascular 
      endothelial function and the expression of inflammatory agents in 
      hyperhomocysteinemic rats. Fifty male Sprague-Dawley rats weighed 145- 155g were 
      on a commercial rat chow diet for seven days, and then were randomized into five 
      groups: normal control group (NC) fed with AOAC diet and four 
      hyperhomocysteinemic groups fed with AOAC diet plus 3% L-methionine. Four 
      hyperhomocysteinemic groups were daily supplemented with 0 (HC), 10 mg/kg (HL1), 
      15 mg/kg (HL2), 20 mg/kg (HL3) lycopene dissolved in corn oil respectively by 
      intragastric administration for 12 weeks. At the end of experiment, their blood 
      and abdominal aortas were collected after etherization. Serum levels of Hcy were 
      determined by HPLC, nitric oxide (NO) and nitric oxide synthase (NOS) by 
      chromatometry, endothelin- 1 (ET-1), vascular cell adhesion molecule-1 (VCAM-1), 
      monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) by ELISA. 
      Hematoxylin and eosin staining and oil red staining were used to analyze 
      abdominal aortas histologically. Moderate hyperhomocysteinemia was induced in 
      hyperhomocysteinemic groups. Serum level of NO was lower and ET-1 was higher in 
      HC rats than in NC, NL2 and NL3 rats (p<0.01). There was no difference of serum 
      NOS activity among five groups. There were some foam cells and depositions of 
      lipochondria in aortic tunica intima in HC and HL1 rats, which were not found in 
      HL2 and HL3 rats. Serum levels of VCAM-1, MCP-1, IL-8 were higher in HC rats than 
      in NC, NL1, NL2 and NL3 rats (p<0.01). The present study indicated that lycopene 
      exerts an antiatherogenic effect by inhibiting the expression of inflammatory 
      agents in hyperhomocysteninemic rats.
FAU - Liu, XiaoJun
AU  - Liu X
AD  - Department of Nutrition, Center of Clinical Nutrition, Changhai Hospital, SMMU, 
      Shanghai 200433, China.
FAU - Qu, Dan
AU  - Qu D
FAU - He, Fang
AU  - He F
FAU - Lu, QiHong
AU  - Lu Q
FAU - Wang, Jin
AU  - Wang J
FAU - Cai, DongLian
AU  - Cai D
LA  - eng
PT  - Journal Article
PL  - China
TA  - Asia Pac J Clin Nutr
JT  - Asia Pacific journal of clinical nutrition
JID - 9440304
RN  - 0 (Antioxidants)
RN  - 0 (Endothelin-1)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 36-88-4 (Carotenoids)
RN  - AE28F7PNPL (Methionine)
RN  - SB0N2N0WV6 (Lycopene)
SB  - IM
MH  - Animals
MH  - Antioxidants/*pharmacology
MH  - Aorta, Abdominal/metabolism/*pathology
MH  - Carotenoids/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Endothelin-1/blood
MH  - Endothelium, Vascular/*drug effects
MH  - Hyperhomocysteinemia/*complications/metabolism/pathology
MH  - Inflammation/etiology
MH  - Lycopene
MH  - Male
MH  - Methionine/administration & dosage
MH  - Nitric Oxide/blood
MH  - Oxidative Stress
MH  - Random Allocation
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Vascular Cell Adhesion Molecule-1/blood
EDAT- 2007/03/30 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/03/30 09:00
PHST- 2007/03/30 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/03/30 09:00 [entrez]
PST - ppublish
SO  - Asia Pac J Clin Nutr. 2007;16 Suppl 1:244-8.