PMID- 17392152 OWN - NLM STAT- MEDLINE DCOM- 20070614 LR - 20070329 IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 16 Suppl 1 DP - 2007 TI - The effects of perinatal protein malnutrition on spatial learning and memory behaviour and brain-derived neurotrophic factor concentration in the brain tissue in young rats. PG - 467-72 AB - This study aimed to investigate the effects of perinatal protein malnutrition on brain derived-neurotrophic factor (BDNF) concentration in brain tissue and spatial learning and memory performance in young rats. Nine pregnant Wistar rats were assigned into three groups. Rats in one group were fed with a control diet containing 20% protein. Rats in remaining two groups were fed with a diet containing 6% protein from gestation day eight and day 15 respectively till four weeks after birth. At four weeks of age, the rat pups were evaluated for spatial learning ability using Morris Water Maze (MWM) task. At the end of the behaviour tests, rat pups were sacrificed and the brain tissue samples were collected for measurement of total protein and BDNF concentrations. It was found that rat pups fed the low protein diet had lower body weight and slightly lighter brain compared to the control pups. Total protein levels in hippocampus and cerebral cortex were significantly lower in malnourished pups than the controls. The concentration of BDNF in the hippocampus was also significantly lower in rat pups suffered protein malnutrition from early pregnancy than in the controls. MWM tests showed that perinatal protein deprivation, particularly from early pregnancy, significantly impaired learning and memory ability. The results of the present study indicate that perinatal protein malnutrition had adverse influence on spatial navigation and brain BDNF levels in rats. The decreased hippocampal BDNF concentration might partially contribute to the poor learning memory performance in the protein deprived rats. FAU - Wang, Ling AU - Wang L AD - Department of Zoology, The University of Hong Kong, Pokfulam Road, Hong Kong. FAU - Xu, Ruo-Jun AU - Xu RJ LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Dietary Proteins) RN - 0 (Proteins) SB - IM MH - Animals MH - Animals, Newborn/*physiology MH - Brain-Derived Neurotrophic Factor/*metabolism MH - Cerebral Cortex/metabolism MH - Dietary Proteins/*administration & dosage/metabolism MH - Female MH - Gene Expression Regulation, Developmental MH - Hippocampus/metabolism MH - Learning MH - Malnutrition MH - Maze Learning/drug effects/*physiology MH - Physical Conditioning, Animal MH - Pregnancy MH - Prenatal Exposure Delayed Effects MH - Proteins/*metabolism MH - Rats MH - Rats, Wistar EDAT- 2007/03/30 09:00 MHDA- 2007/06/15 09:00 CRDT- 2007/03/30 09:00 PHST- 2007/03/30 09:00 [pubmed] PHST- 2007/06/15 09:00 [medline] PHST- 2007/03/30 09:00 [entrez] PST - ppublish SO - Asia Pac J Clin Nutr. 2007;16 Suppl 1:467-72.