PMID- 1739225
OWN - NLM
STAT- MEDLINE
DCOM- 19920319
LR  - 20061115
IS  - 0003-1348 (Print)
IS  - 0003-1348 (Linking)
VI  - 58
IP  - 1
DP  - 1992 Jan
TI  - Acute limited normovolemic hemodilution can be safely used in a malnourished 
      model.
PG  - 22-7
AB  - This study investigates the effects of acute limited normovolemic hemodilution 
      (ALNH) on intestinal healing in a malnourished animal model. Twenty rabbits were 
      randomized into three Groups: Group 1 = control; Group 2 = ALNH (removal 35% 
      blood volume and maintenance of normovolemia with 3:1 crystalloid infusion) 
      followed by retransfusion (RT) after small bowel anastomosis (ANA). Group 3 had a 
      restricted diet for 3 weeks preoperatively to cause a 15 percent to 20 percent 
      weight loss. A six cm segment of small bowel (SB) was resected and anastomosed 
      (ANA) in all animals. Blood pressure (BP), transserosal oxygen tension (TsPao2), 
      hematocrit (Hct), colloid oncotic pressure (COP), wet-to-dry weight ratios 
      (WW/DW), hydroxyproline (OH-Pro) content, and tensile strength (TS) of the ANA 
      and a segment of adjacent SB were determined. BP did not change from baseline 
      (BL) in Group 2 during ALNH; however, it rose significantly after RT (P less than 
      0.05). BP decreased significantly during ALNH in Group 3 (P less than 0.05) and 
      did not rise above baseline after RT. There was no significant change in TsPao2 
      from BL within groups during the experiment. The Hct and COP decreased 
      significantly after ALNH in Groups 2 and 3 after ALNH compared to BL (P less than 
      0.05). After RT the Hct and COP increased and by Day 8 the Hct had risen to BL 
      values in Group 3 but not in Group 2 (P less than 0.05), whereas COP values were 
      not significantly different from BL in either group. There was no difference in 
      WW/DW or TS between or among the three groups.(ABSTRACT TRUNCATED AT 250 WORDS)
FAU - Woloszyn, T T
AU  - Woloszyn TT
AD  - Department of Surgery, Maimonides Medical Center, Brooklyn, New York.
FAU - Coons, M S
AU  - Coons MS
FAU - Rodriguez, C
AU  - Rodriguez C
FAU - Levy, R
AU  - Levy R
FAU - Heaney, M
AU  - Heaney M
FAU - Wang, S
AU  - Wang S
FAU - Marini, C P
AU  - Marini CP
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am Surg
JT  - The American surgeon
JID - 0370522
SB  - IM
MH  - Anastomosis, Surgical
MH  - Animals
MH  - *Blood Volume
MH  - *Disease Models, Animal
MH  - Hemodilution/*methods
MH  - Intestine, Small/physiopathology/surgery
MH  - Postoperative Period
MH  - Protein-Energy Malnutrition/physiopathology/*therapy
MH  - Rabbits
MH  - Wound Healing
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Am Surg. 1992 Jan;58(1):22-7.