PMID- 17392612
OWN - NLM
STAT- MEDLINE
DCOM- 20070605
LR  - 20191110
IS  - 1527-5299 (Print)
IS  - 1527-5299 (Linking)
VI  - 13
IP  - 2
DP  - 2007 Mar-Apr
TI  - Cardiac resynchronization therapy: from creation to evolution--an evidence-based 
      review.
PG  - 84-92
AB  - In the past decade, cardiac resynchronization therapy (CRT), achieved by 
      simultaneous left and right ventricular pacing, has emerged as a potent 
      therapeutic option for patients with congestive heart failure. Electrical 
      dyssynchrony, most often manifested by left bundle branch block on the surface 
      12-lead electrocardiogram, results in mechanical dyssynchrony of the left 
      ventricular septum and free wall, which decreases cardiac efficiency. In patients 
      with ejection fractions <30%, New York Heart Association (NYHA) class III or IV, 
      and QRS width >120 ms, CRT improves clinical parameters such as 6-minute walk 
      distances, quality-of-life scores, and NYHA functional class. Long-term reverse 
      remodeling of the failing ventricle results in reductions in congestive heart 
      failure hospitalizations and mortality independent of defibrillator therapy. 
      While most patients show significant improvement, a small proportion fail to 
      respond. Appropriately identifying patients who will benefit most from CRT and 
      timing the initiation of resynchronization therapy remain areas of intense 
      investigation.
FAU - Mark, George E
AU  - Mark GE
AD  - Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA 
      19107, USA.
FAU - Rhim, Eugene S
AU  - Rhim ES
FAU - Feldman, Arthur M
AU  - Feldman AM
FAU - Pavri, Behzad B
AU  - Pavri BB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Congest Heart Fail
JT  - Congestive heart failure (Greenwich, Conn.)
JID - 9714174
SB  - IM
MH  - Arrhythmias, Cardiac/therapy
MH  - Cardiac Pacing, Artificial/*trends
MH  - Heart Failure/*therapy
MH  - Humans
RF  - 50
EDAT- 2007/03/30 09:00
MHDA- 2007/06/06 09:00
CRDT- 2007/03/30 09:00
PHST- 2007/03/30 09:00 [pubmed]
PHST- 2007/06/06 09:00 [medline]
PHST- 2007/03/30 09:00 [entrez]
AID - 10.1111/j.1527-5299.2007.888126.x [doi]
PST - ppublish
SO  - Congest Heart Fail. 2007 Mar-Apr;13(2):84-92. doi: 
      10.1111/j.1527-5299.2007.888126.x.