PMID- 17392738
OWN - NLM
STAT- MEDLINE
DCOM- 20080214
LR  - 20220410
IS  - 0893-133X (Print)
IS  - 0893-133X (Linking)
VI  - 32
IP  - 12
DP  - 2007 Dec
TI  - Interaction between BDNF Val66Met and dopamine transporter gene variation 
      influences anxiety-related traits.
PG  - 2552-60
AB  - The involvement in neural plasticity and the mediation of effects of repeated 
      stress exposure and long-term antidepressant treatment on hippocampal 
      neurogenesis supports a critical role of brain-derived neurotrophic factor (BDNF) 
      in the pathophysiology of affective and other stress-related disorders. A 
      previously reported valine to methionine substitution at amino-acid position 66 
      (BDNF Val66Met) seems to account for memory disturbance and hippocampal 
      dysfunction. In the present study, we evaluated the impact of the BDNF Val66Met 
      polymorphism on individual differences in personality traits in a sample of 
      healthy volunteers in relation to other common gene variants thought to be 
      involved in the pathophysiology of affective disorders, such as the serotonin 
      transporter promoter polymorphism (5-HTTLPR) and a variable number of tandem 
      repeat polymorphism of the dopamine transporter gene (DAT VNTR). Personality 
      traits were assessed using the NEO personality inventory (NEO-PI-R) and 
      Tridimensional Personality Questionnaire (TPQ). There was a significant DAT 
      VNTR-dependent association between NEO-PI-R Neuroticism and the BDNF Val66Met 
      polymorphism. Among individuals with at least one copy of the DAT 9-repeat 
      allele, carriers of the BDNF Met allele exhibited significantly lower Neuroticism 
      scores than noncarriers. This interaction was also observed for TPQ Harm 
      Avoidance, a personality dimension related to Neuroticism. Our results support 
      the notion that allelic variation at the BDNF locus--in interaction with other 
      gene variants--influences anxiety- and depression-related personality traits.
FAU - Hunnerkopf, Regina
AU  - Hunnerkopf R
AD  - Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, 
      University of Wurzburg, Wurzburg, Germany.
FAU - Strobel, Alexander
AU  - Strobel A
FAU - Gutknecht, Lise
AU  - Gutknecht L
FAU - Brocke, Burkhard
AU  - Brocke B
FAU - Lesch, Klaus Peter
AU  - Lesch KP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070328
PL  - England
TA  - Neuropsychopharmacology
JT  - Neuropsychopharmacology : official publication of the American College of 
      Neuropsychopharmacology
JID - 8904907
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Anxiety/*genetics
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Dopamine Plasma Membrane Transport Proteins/*genetics
MH  - Female
MH  - *Genetic Variation
MH  - Genotype
MH  - Humans
MH  - Individuality
MH  - Male
MH  - Methionine/*genetics
MH  - Minisatellite Repeats/genetics
MH  - Personality Inventory
MH  - Surveys and Questionnaires
MH  - Valine/*genetics
EDAT- 2007/03/30 09:00
MHDA- 2008/02/15 09:00
CRDT- 2007/03/30 09:00
PHST- 2007/03/30 09:00 [pubmed]
PHST- 2008/02/15 09:00 [medline]
PHST- 2007/03/30 09:00 [entrez]
AID - 1301383 [pii]
AID - 10.1038/sj.npp.1301383 [doi]
PST - ppublish
SO  - Neuropsychopharmacology. 2007 Dec;32(12):2552-60. doi: 10.1038/sj.npp.1301383. 
      Epub 2007 Mar 28.