PMID- 17393453
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20071213
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 56
IP  - 4
DP  - 2007 Apr
TI  - Interleukin-6 and chemokines in the neuropsychiatric manifestations of systemic 
      lupus erythematosus.
PG  - 1242-50
AB  - OBJECTIVE: To define the cytokine and chemokine profile in cerebrospinal fluid 
      (CSF) from patients with neuropsychiatric systemic lupus erythematosus (NPSLE). 
      METHODS: Forty-two SLE patients who had been hospitalized because of NP 
      manifestations were studied. Patients were evaluated at hospitalization and 6 
      months later; a CSF sample was obtained at each evaluation. As controls, CSF from 
      6 SLE patients with septic meningitis, 16 SLE patients with no history of NP 
      manifestations (non-NPSLE), and 25 patients with nonautoimmune diseases were also 
      studied. Soluble molecules, including cytokines (interleukin-2 [IL-2], IL-4, 
      IL-6, IL-10, tumor necrosis factor alpha [TNFalpha], and interferon-gamma 
      [IFNgamma]) and chemokines (monocyte chemotactic protein 1 [MCP-1], RANTES, IL-8, 
      monokine induced by IFNgamma [MIG], and interferon-gamma-inducible 10-kd protein 
      [IP-10]), were measured with the use of cytometric bead array kits. RESULTS: CSF 
      levels of the following molecules were significantly increased in NPSLE patients 
      as compared with non-NPSLE and nonautoimmune diseases control patients, 
      respectively: IL-6 (32.7 versus 3.0 and 2.96 pg/ml), IL-8 (102.8 versus 29.97 and 
      19.7 pg/ml), IP-10 (888.2 versus 329.7 [P not significant] and 133.6 pg/ml), 
      RANTES (3.8 versus 2.5 and 2.2 pg/ml), MCP-1 (401.7 versus 257.9 [P not 
      significant] and 136.9 pg/ml), and MIG (35.4 versus 11.4 and 3.5 pg/ml). Low 
      levels of IL-2, IL-4, IL-10, TNFalpha, and IFNgamma were found in all groups. All 
      cytokines and chemokines, except TNFalpha, were significantly higher among the 
      SLE patients with septic meningitis than among the NPSLE patients. Six months 
      later and in the absence of NP manifestations, all elevated molecule levels, 
      except RANTES, in patients with NPSLE had decreased significantly, and no 
      differences were noted between the NPSLE and non-NPSLE groups. CONCLUSION: A 
      central nervous system response composed of IL-6 and chemokines, but not Th1/Th2 
      cytokines, is associated with NP manifestations in SLE patients.
FAU - Fragoso-Loyo, H
AU  - Fragoso-Loyo H
AD  - Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Medicas 
      y Nutricion Salvador Zubiran, Mexico, DF, Tlalpan, Mexico.
FAU - Richaud-Patin, Y
AU  - Richaud-Patin Y
FAU - Orozco-Narvaez, A
AU  - Orozco-Narvaez A
FAU - Davila-Maldonado, L
AU  - Davila-Maldonado L
FAU - Atisha-Fregoso, Y
AU  - Atisha-Fregoso Y
FAU - Llorente, L
AU  - Llorente L
FAU - Sanchez-Guerrero, J
AU  - Sanchez-Guerrero J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Chemokines)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
SB  - IM
CIN - Arthritis Rheum. 2007 Oct;56(10):3509; author reply 3509-10. PMID: 17907179
MH  - Adult
MH  - Chemokines/*cerebrospinal fluid
MH  - Cytokines/cerebrospinal fluid
MH  - Female
MH  - Humans
MH  - Interleukin-6/*cerebrospinal fluid
MH  - Lupus Erythematosus, Systemic
MH  - Lupus Vasculitis, Central Nervous System/*cerebrospinal 
      fluid/diagnosis/*psychology
MH  - Male
MH  - Meningitis, Bacterial/cerebrospinal fluid
MH  - Severity of Illness Index
EDAT- 2007/03/30 09:00
MHDA- 2007/05/11 09:00
CRDT- 2007/03/30 09:00
PHST- 2007/03/30 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2007/03/30 09:00 [entrez]
AID - 10.1002/art.22451 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2007 Apr;56(4):1242-50. doi: 10.1002/art.22451.