PMID- 17394022
OWN - NLM
STAT- MEDLINE
DCOM- 20090414
LR  - 20210119
IS  - 0931-041X (Print)
IS  - 1432-198X (Electronic)
IS  - 0931-041X (Linking)
VI  - 23
IP  - 12
DP  - 2008 Dec
TI  - Biomarkers for the early detection of acute kidney injury.
PG  - 2151-7
AB  - Acute kidney injury (AKI), previously referred to as acute renal failure (ARF), 
      represents a persistent problem in clinical medicine. Despite significant 
      improvements in therapeutics, the mortality and morbidity associated with AKI 
      remain high. A major reason for this is the lack of early markers for AKI, akin 
      to troponins in acute myocardial disease, and hence an unacceptable delay in 
      initiating therapy. Fortunately, the application of innovative technologies such 
      as functional genomics and proteomics to human and animal models of AKI has 
      uncovered several novel genes and gene products that are emerging as biomarkers. 
      The most promising of these are chronicled in this article. These include a 
      plasma panel [neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C] 
      and a urine panel [NGAL, interleukin 18 (IL-18), and kidney injury molecule 1 
      (KIM)-1]. As they represent sequentially expressed biomarkers, it is likely that 
      the AKI panels will be useful for timing the initial insult and assessing the 
      duration of AKI. Based on the differential expression of the biomarkers, it is 
      also likely that the AKI panels will distinguish between the various types and 
      etiologies of AKI. It will be important in future studies to validate the 
      sensitivity and specificity of these biomarker panels in clinical samples from 
      large cohorts and from multiple clinical situations.
FAU - Nguyen, Mai T
AU  - Nguyen MT
AD  - Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
FAU - Devarajan, Prasad
AU  - Devarajan P
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20070330
PL  - Germany
TA  - Pediatr Nephrol
JT  - Pediatric nephrology (Berlin, Germany)
JID - 8708728
RN  - 0 (Acute-Phase Proteins)
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - 0 (HAVCR1 protein, human)
RN  - 0 (Hepatitis A Virus Cellular Receptor 1)
RN  - 0 (Interleukin-18)
RN  - 0 (LCN2 protein, human)
RN  - 0 (Lipocalin-2)
RN  - 0 (Lipocalins)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Receptors, Virus)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Acute Kidney Injury/*diagnosis/*metabolism/physiopathology
MH  - Acute-Phase Proteins/*urine
MH  - Animals
MH  - Biomarkers/*blood/*urine
MH  - Creatinine/blood
MH  - Cystatin C/blood
MH  - Disease Models, Animal
MH  - Glomerular Filtration Rate/physiology
MH  - Hepatitis A Virus Cellular Receptor 1
MH  - Humans
MH  - Interleukin-18/urine
MH  - Lipocalin-2
MH  - Lipocalins/*blood/*urine
MH  - Membrane Glycoproteins/urine
MH  - Proto-Oncogene Proteins/*blood/*urine
MH  - Receptors, Virus
MH  - Renal Replacement Therapy
PMC - PMC6904376
EDAT- 2007/03/31 09:00
MHDA- 2009/04/15 09:00
PMCR- 2008/12/01
CRDT- 2007/03/31 09:00
PHST- 2007/02/21 00:00 [received]
PHST- 2007/02/22 00:00 [accepted]
PHST- 2007/02/21 00:00 [revised]
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2009/04/15 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 470 [pii]
AID - 10.1007/s00467-007-0470-x [doi]
PST - ppublish
SO  - Pediatr Nephrol. 2008 Dec;23(12):2151-7. doi: 10.1007/s00467-007-0470-x. Epub 
      2007 Mar 30.