PMID- 17394153
OWN - NLM
STAT- MEDLINE
DCOM- 20070613
LR  - 20070416
IS  - 1527-6465 (Print)
IS  - 1527-6465 (Linking)
VI  - 13
IP  - 4
DP  - 2007 Apr
TI  - Combined HLA-DR and -DQ disparity is associated with a stable course of 
      ulcerative colitis after liver transplantation for primary sclerosing 
      cholangitis.
PG  - 552-7
AB  - Combined disparity of human leukocyte antigen (HLA)-DR and -DQ between mother and 
      fetus is associated with less severe ulcerative colitis (UC) during pregnancy. We 
      evaluated whether donor-recipient HLA disparity after liver transplantation (LT) 
      affects UC in patients with primary sclerosing cholangitis (PSC). Sixty-nine 
      consecutive patients with PSC underwent LT; all underwent colonoscopy before LT; 
      48 had UC before and 3 had de novo UC after LT. Clinical and laboratory data, 
      activity and treatment of UC, post-LT cytomegalovirus infection, and disparity of 
      HLA-A, -B, -DR, and -DQ for each donor-recipient pair were evaluated. Pre-LT 
      quiescent UC was present in 26 patients. Post-LT UC activity was evaluated in 36 
      of 51 patients with UC who had not undergone pre-LT colectomy and who had >12 
      months' post-LT survival. Of these, 16 were stable, 17 had worsened, and 3 had de 
      novo UC. Seven required colectomy (4 for dysplasia or cancer) after LT. Post-LT 
      cytomegalovirus viremia was neither associated with worse UC activity (P = 0.58) 
      nor de novo UC. Disparity with respect to HLA-A, -B, -DR, and -DQ was found in 
      58%, 27%, 44%, and 39% donor-recipient pairs, respectively. Post-LT UC course was 
      similar with respect to single HLA disparity. However, disparity in none or only 
      one HLA-DR or -DQ was significantly associated with worse activity compared with 
      patients with disparity at both (65% vs. 0%, P = 0.009). Logistic regression 
      found that the disparity for both -DR and -DQ was the only factor statistically 
      significantly associated with post-LT UC activity. We conclude that disparity in 
      both HLA-DR and -DQ between donor and recipient is associated with stable UC 
      activity after LT.
FAU - Cholongitas, Evangelos
AU  - Cholongitas E
AD  - Liver Transplantation and Hepatobiliary Unit, Royal Free Hospital, Hampstead, 
      London, UK.
FAU - Papatheodoridis, George V
AU  - Papatheodoridis GV
FAU - Zappoli, Paola
AU  - Zappoli P
FAU - Giannakopoulos, Athanasios
AU  - Giannakopoulos A
FAU - Patch, David
AU  - Patch D
FAU - Marelli, Laura
AU  - Marelli L
FAU - Shusang, Vibhakorn
AU  - Shusang V
FAU - Kalambokis, George
AU  - Kalambokis G
FAU - Shirling, Graham
AU  - Shirling G
FAU - Rolando, Nancy
AU  - Rolando N
FAU - Burroughs, A K
AU  - Burroughs AK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Liver Transpl
JT  - Liver transplantation : official publication of the American Association for the 
      Study of Liver Diseases and the International Liver Transplantation Society
JID - 100909185
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cholangiocarcinoma/epidemiology
MH  - Cholangitis, Sclerosing/*surgery
MH  - Colitis, Ulcerative/*immunology
MH  - Female
MH  - HLA-DQ Antigens/*immunology
MH  - HLA-DR Antigens/*immunology
MH  - Histocompatibility Testing
MH  - Humans
MH  - Liver Neoplasms/epidemiology
MH  - Liver Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/*immunology
MH  - Retrospective Studies
MH  - Treatment Outcome
EDAT- 2007/03/31 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/03/31 09:00
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
AID - 10.1002/lt.21077 [doi]
PST - ppublish
SO  - Liver Transpl. 2007 Apr;13(4):552-7. doi: 10.1002/lt.21077.