PMID- 17395049
OWN - NLM
STAT- MEDLINE
DCOM- 20070508
LR  - 20220310
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Print)
IS  - 1071-9164 (Linking)
VI  - 13
IP  - 2
DP  - 2007 Mar
TI  - Pulmonary function changes associated with cardiomegaly in chronic heart failure.
PG  - 100-7
AB  - BACKGROUND: This study examined the influence of increased cardiac size on 
      maximal lung volumes, forced expiratory airflows, and the diffusing capacity of 
      the lungs in heart failure (HF) patients compared with controls. METHODS AND 
      RESULTS: Forty-one HF patients of New York Heart Association (NYHA) class: Group 
      A = class I/II (n = 26) and Group B = class III/IV (n = 15) and an equal number 
      matched controls (CTL) were recruited. Participants underwent echocardiography, 
      spirometry, and posteroanterior and lateral chest radiographic evaluation (RAD) 
      for volumetric estimation of the total thoracic cavity (TTC), diaphragm, heart, 
      and lungs. Analysis of variance demonstrated no difference between groups for TTC 
      volume (P = .63). RAD cardiac volumes (% TTC volume) were significantly different 
      among all groups (P < .001). Echocardiograms determined left ventricular mass was 
      elevated in the HF groups compared with the CTL group (P < .001) with no 
      difference between HF groups. Lung volume (% TTC volume) was reduced as a 
      function of disease severity (P < .001). RAD measures of cardiac volume 
      demonstrated the strongest relationship with restrictive lung alterations 
      (t-statistic = -5.627, P < .001 and t-statistic = -4.378, P < .001 for forced 
      vital capacity and forced expiratory volume in 1 second, respectively). 
      CONCLUSIONS: These results suggest cardiac size may pose significant constraints 
      on the lungs and likely plays a major role in the restrictive breathing patterns 
      often reported in HF patients.
FAU - Olson, Thomas P
AU  - Olson TP
AD  - Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic 
      and Foundation, Rochester, Minnesota 55905, USA.
FAU - Beck, Kenneth C
AU  - Beck KC
FAU - Johnson, Bruce D
AU  - Johnson BD
LA  - eng
GR  - R01 HL071478/HL/NHLBI NIH HHS/United States
GR  - HL71478/HL/NHLBI NIH HHS/United States
GR  - T32 HL007111/HL/NHLBI NIH HHS/United States
GR  - HL07111/HL/NHLBI NIH HHS/United States
GR  - R01 HL071478-05/HL/NHLBI NIH HHS/United States
GR  - T32 HL007111-30/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Disease Progression
MH  - Echocardiography, Doppler
MH  - Female
MH  - Forced Expiratory Flow Rates/*physiology
MH  - Heart Failure/diagnostic imaging/*physiopathology
MH  - Humans
MH  - Lung/diagnostic imaging/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Pulmonary Diffusing Capacity/*physiology
MH  - Radiography, Thoracic
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke Volume/physiology
PMC - PMC1941841
MID - NIHMS21345
EDAT- 2007/03/31 09:00
MHDA- 2007/05/09 09:00
PMCR- 2008/03/01
CRDT- 2007/03/31 09:00
PHST- 2006/05/02 00:00 [received]
PHST- 2006/08/19 00:00 [revised]
PHST- 2006/10/27 00:00 [accepted]
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2007/05/09 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
PHST- 2008/03/01 00:00 [pmc-release]
AID - S1071-9164(06)01226-7 [pii]
AID - 10.1016/j.cardfail.2006.10.018 [doi]
PST - ppublish
SO  - J Card Fail. 2007 Mar;13(2):100-7. doi: 10.1016/j.cardfail.2006.10.018.