PMID- 17395157
OWN - NLM
STAT- MEDLINE
DCOM- 20070628
LR  - 20070411
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 356
IP  - 4
DP  - 2007 May 18
TI  - Pro-region of neurotrophins determines the processing efficiency.
PG  - 919-24
AB  - Neurotrophins are synthesized as precursors called pro-neurotrophins and then 
      mature neurotrophins are formed proteolytically from them. Recent findings 
      revealed that pro- and mature neurotrophins elicit opposite functional effects on 
      cell survival, highlighting the importance of this processing step. Nerve growth 
      factor (NGF) and brain-derived neurotrophic factor (BDNF) belong to the 
      neurotrophin family and are mutually homologous, but BDNF is less efficiently 
      processed. In order to find the reason for this, we examined some possibilities 
      by using PC12 cells, and found that the pro-region, especially the last half of 
      it, affected very much the processing efficiency of these neurotrophins.
FAU - Nomoto, Hiroshi
AU  - Nomoto H
AD  - Laboratory of Molecular Biology, Gifu Pharmaceutical University, Gifu 502-8585, 
      Japan. hnomoto@gifu-pu.ac.jp
FAU - Takaiwa, Masatoshi
AU  - Takaiwa M
FAU - Mouri, Akihiro
AU  - Mouri A
FAU - Furukawa, Shoei
AU  - Furukawa S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070319
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*chemistry/*metabolism
MH  - Gene Expression/physiology
MH  - Molecular Sequence Data
MH  - Nerve Growth Factor/*chemistry/*metabolism
MH  - Nerve Growth Factors/chemistry/metabolism
MH  - PC12 Cells
MH  - Protein Structure, Tertiary
MH  - Rats
MH  - Structure-Activity Relationship
EDAT- 2007/03/31 09:00
MHDA- 2007/06/29 09:00
CRDT- 2007/03/31 09:00
PHST- 2007/03/09 00:00 [received]
PHST- 2007/03/10 00:00 [accepted]
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2007/06/29 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
AID - S0006-291X(07)00545-1 [pii]
AID - 10.1016/j.bbrc.2007.03.059 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 May 18;356(4):919-24. doi: 
      10.1016/j.bbrc.2007.03.059. Epub 2007 Mar 19.