PMID- 17395388
OWN - NLM
STAT- MEDLINE
DCOM- 20070703
LR  - 20131121
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 146
IP  - 3
DP  - 2007 May 25
TI  - Expression of brain-derived neurotrophic factor in the rat forebrain and upper 
      brain stem during postnatal development: an immunohistochemical study.
PG  - 1128-36
AB  - The present study was undertaken to characterize the regional and temporal 
      patterns of brain-derived neurotrophic factor (BDNF) in the rat forebrain and 
      upper brain stem during postnatal development using an immunohistochemical 
      approach. Results indicated that BDNF-immunoreactive (IR) cells could be divided 
      into three groups based on their postnatal developmental patterns: (group 1) 
      BDNF-IR cells were first detected between postnatal days (PND) 1 and 7, and 
      thereafter they increased in number and remained stable during later stages of 
      ontogeny; (group 2) BDNF-IR cells progressively increased in number with age, and 
      then decreased in adults; (group 3) numerous BDNF-IR cells detected between PND 1 
      and 7 showed a dramatic reductions in number with few IR cells in adults. In 
      contrast, the developmental pattern of most BDNF-IR fibers differed from that of 
      IR neurons, i.e. they appeared between PND 1-28 and thereafter continued to 
      increase in number showing a maximum level in adults. Additionally, BDNF-IR cells 
      in the superficial layer of the neocortex and IR fibers in the stratum oriens of 
      CA2 first appeared as late as PND 28 and in adults, respectively. After 
      colchicine treatment, reexpression or a marked increase in the number of BDNF-IR 
      neurons was observed in many areas of the adult brain where a progressive 
      decrease in BDNF-IR cell numbers during development and scant or some IR neurons 
      in adults were shown. These results showed both transient and persistent 
      expression of BDNF in various regions of the developing rat brain.
FAU - Kim, J K
AU  - Kim JK
AD  - Department of Occupational Therapy, Daegu Health College, San 7, Taejeon-1 Dong, 
      Buk-gu, Daegu 702-867, South Korea.
FAU - Jeon, S M
AU  - Jeon SM
FAU - Lee, K M
AU  - Lee KM
FAU - Park, E S
AU  - Park ES
FAU - Cho, H J
AU  - Cho HJ
LA  - eng
PT  - Journal Article
DEP - 20070328
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - SML2Y3J35T (Colchicine)
SB  - IM
MH  - Animals
MH  - Animals, Newborn/*physiology
MH  - Brain Stem/cytology/growth & development/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis
MH  - Cell Count
MH  - Colchicine/pharmacology
MH  - Diencephalon/growth & development/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Mesencephalon/growth & development/metabolism
MH  - Nerve Fibers/metabolism
MH  - Neurons/drug effects/metabolism
MH  - Prosencephalon/cytology/growth & development/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Telencephalon/growth & development/metabolism
EDAT- 2007/03/31 09:00
MHDA- 2007/07/04 09:00
CRDT- 2007/03/31 09:00
PHST- 2006/12/06 00:00 [received]
PHST- 2007/02/05 00:00 [revised]
PHST- 2007/02/10 00:00 [accepted]
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2007/07/04 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
AID - S0306-4522(07)00177-7 [pii]
AID - 10.1016/j.neuroscience.2007.02.017 [doi]
PST - ppublish
SO  - Neuroscience. 2007 May 25;146(3):1128-36. doi: 
      10.1016/j.neuroscience.2007.02.017. Epub 2007 Mar 28.