PMID- 17396103
OWN - NLM
STAT- MEDLINE
DCOM- 20070709
LR  - 20111117
IS  - 1466-4879 (Print)
IS  - 1466-4879 (Linking)
VI  - 8
IP  - 4
DP  - 2007 Jun
TI  - HLA-DRB1*04 and DRB1*10 are associated with resistance and susceptibility, 
      respectively, in Brazilian and Vietnamese leprosy patients.
PG  - 320-4
AB  - The host genetic background has been considered one of the factors that influence 
      leprosy outcome, a chronic infectious disease caused by Mycobacterium leprae. 
      Genome scans demonstrated that the 6p21 region is associated with leprosy and a 
      substantial number of population-based studies analyzing human leukocyte antigen 
      (HLA) class II loci suggested association of HLA-DR with leprosy. However, some 
      studies lacked robustness as they had limited power. Indeed, experimental designs 
      require increased sample size to achieve adequate power, as well as replication 
      studies with independent samples for confirmation of previous findings. In this 
      work, we analyzed the influence of the HLA-DRB1 locus on leprosy susceptibility 
      per se and disease type using a case-control design carried out in Brazilians 
      (578 cases and 691 controls) and a replication study based on a family design in 
      a Vietnamese population (n=194 families). The results showed that HLA-DRB1*10 is 
      associated with susceptibility to leprosy and HLA-DRB1*04 is associated with 
      resistance, both in the Brazilian and Vietnamese populations suggesting that 
      these alleles play an important role in the activation of cellular immune 
      responses against M. leprae.
FAU - Vanderborght, P R
AU  - Vanderborght PR
AD  - Leprosy Laboratory, Department of Mycobacterioses, Oswaldo Cruz Institute, 
      FIOCRUZ, Av. Brasil 4365, Manguinhos, Rio de Janeiro 21045-900, RJ, Brazil.
FAU - Pacheco, A G
AU  - Pacheco AG
FAU - Moraes, M E
AU  - Moraes ME
FAU - Antoni, G
AU  - Antoni G
FAU - Romero, M
AU  - Romero M
FAU - Verville, A
AU  - Verville A
FAU - Thai, V H
AU  - Thai VH
FAU - Huong, N T
AU  - Huong NT
FAU - Ba, N N
AU  - Ba NN
FAU - Schurr, E
AU  - Schurr E
FAU - Sarno, E N
AU  - Sarno EN
FAU - Moraes, M O
AU  - Moraes MO
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070329
PL  - England
TA  - Genes Immun
JT  - Genes and immunity
JID - 100953417
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Alleles
MH  - Brazil
MH  - *Genetic Predisposition to Disease
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Humans
MH  - Immunity, Innate
MH  - Leprosy/*genetics/*immunology
MH  - Vietnam
EDAT- 2007/03/31 09:00
MHDA- 2007/07/10 09:00
CRDT- 2007/03/31 09:00
PHST- 2007/03/31 09:00 [pubmed]
PHST- 2007/07/10 09:00 [medline]
PHST- 2007/03/31 09:00 [entrez]
AID - 6364390 [pii]
AID - 10.1038/sj.gene.6364390 [doi]
PST - ppublish
SO  - Genes Immun. 2007 Jun;8(4):320-4. doi: 10.1038/sj.gene.6364390. Epub 2007 Mar 29.