PMID- 17397242
OWN - NLM
STAT- MEDLINE
DCOM- 20070621
LR  - 20191210
IS  - 1177-1062 (Print)
IS  - 1177-1062 (Linking)
VI  - 11
IP  - 2
DP  - 2007
TI  - Comparative genomic hybridization arrays in clinical pathology: progress and 
      challenges.
PG  - 73-7
AB  - Array-based comparative genomic hybridization (array CGH) genome scanning is a 
      powerful method for the global detection of gains and losses of genetic material 
      in both congenital and neoplastic disorders. When used as a clinical diagnostic 
      test, array CGH combines the whole genome perspective of traditional G-banded 
      cytogenetics with the targeted identification of cryptic chromosomal 
      abnormalities characteristic of fluorescence in situ hybridization (FISH). 
      However, the presence of structural variants in the human genome can complicate 
      analysis of patient samples, and array CGH does not provide morphologic 
      information about chromosome structure, balanced translocations, or the actual 
      chromosomal location of segmental duplications. Identification of such anomalies 
      has significant diagnostic and prognostic implications for the patient. We 
      therefore propose that array CGH should be used as a guide to the presence of 
      genomic structural rearrangements in germline and tumor genomes that can then be 
      further characterized by FISH or G-banding, depending on the clinical scenario. 
      In this article, we share some of our experiences with diagnostic array CGH and 
      discuss recent progress and challenges involved with the integration of array CGH 
      into clinical laboratory medicine.
FAU - Gunn, Shelly R
AU  - Gunn SR
AD  - Department of Pathology, University of Texas Health Science Center, San Antonio, 
      Texas 78229-3900, USA. gunn@uthscsa.edu
FAU - Robetorye, Ryan S
AU  - Robetorye RS
FAU - Mohammed, Mansoor S
AU  - Mohammed MS
LA  - eng
GR  - P30 CA54174/CA/NCI NIH HHS/United States
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - New Zealand
TA  - Mol Diagn Ther
JT  - Molecular diagnosis & therapy
JID - 101264260
SB  - IM
MH  - Chromosome Banding
MH  - Congenital Abnormalities/diagnosis
MH  - Gene Dosage
MH  - Genes, Neoplasm
MH  - Genome, Human
MH  - Humans
MH  - Microarray Analysis/*methods
MH  - Molecular Diagnostic Techniques
MH  - Nucleic Acid Hybridization/*methods
MH  - Pathology, Clinical/*methods/*trends
RF  - 13
EDAT- 2007/04/03 09:00
MHDA- 2007/06/22 09:00
CRDT- 2007/04/03 09:00
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2007/06/22 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - 1122 [pii]
AID - 10.1007/BF03256225 [doi]
PST - ppublish
SO  - Mol Diagn Ther. 2007;11(2):73-7. doi: 10.1007/BF03256225.