PMID- 17398080
OWN - NLM
STAT- MEDLINE
DCOM- 20070710
LR  - 20080417
IS  - 0165-1781 (Print)
IS  - 0165-1781 (Linking)
VI  - 155
IP  - 1
DP  - 2007 May 15
TI  - Fronto-limbic and autonomic disjunctions to negative emotion distinguish 
      schizophrenia subtypes.
PG  - 29-44
AB  - Schizophrenia patients show a disconnection in amygdala-medial prefrontal cortex 
      and autonomic arousal systems for processing fear. Concurrent functional magnetic 
      resonance imaging [fMRI] and skin conductance recording were used to determine 
      whether these disturbances are specific to fear, or present in response to other 
      signals of danger. We also examined whether these disturbances distinguish a 
      specific symptom profile. During scanning, 27 schizophrenia (13 paranoid, 14 
      nonparanoid) and 22 matched healthy control subjects viewed standardized facial 
      expressions of fear, anger and disgust (versus neutral). Skin conductance 
      responses [SCRs]were acquired simultaneously to assess phasic increases in 
      arousal. 'With-arousal' versus 'without-arousal' responses were analysed using 
      non-parametric methods. For controls, 'with-arousal' responses were associated 
      with emotion-specific activity for fear (amygdala), disgust (insula) and anger 
      (anterior cingulate), together with common medial prefrontal cortex [MPFC] 
      engagement, as predicted. Schizophrenia patients displayed abnormally increased 
      phasic arousal, with concomitant reductions in emotion-specific regions and MPFC. 
      These findings may reflect a general disconnection between central and autonomic 
      systems for processing signals of danger. This disjunction was most apparent in 
      patients with a profile of paranoia, coupled with poor social function and 
      insight. Heightened autonomic sensitivity to signals of fear, threat or 
      contamination, without effective neural mechanisms for appraisal, may underlie 
      paranoid delusions which concern threat and contamination, and associated social 
      and interpersonal difficulties.
FAU - Williams, Leanne M
AU  - Williams LM
AD  - Brain Dynamics Centre, Westmead Hospital, NSW, 2145, Australia. 
      lea@psych.usyd.edu.au
FAU - Das, Pritha
AU  - Das P
FAU - Liddell, Belinda J
AU  - Liddell BJ
FAU - Olivieri, Gloria
AU  - Olivieri G
FAU - Peduto, Anthony S
AU  - Peduto AS
FAU - David, Anthony S
AU  - David AS
FAU - Gordon, Evian
AU  - Gordon E
FAU - Harris, Anthony W F
AU  - Harris AW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070330
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
SB  - IM
MH  - Adult
MH  - *Affect
MH  - Amygdala/physiopathology
MH  - Anger
MH  - Cerebral Cortex/physiopathology
MH  - Fear
MH  - Frontal Lobe/*physiopathology
MH  - Galvanic Skin Response
MH  - Humans
MH  - Limbic System/*physiopathology
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prefrontal Cortex/physiopathology
MH  - Schizophrenia/*diagnosis
MH  - *Schizophrenic Psychology
MH  - Severity of Illness Index
EDAT- 2007/04/03 09:00
MHDA- 2007/07/11 09:00
CRDT- 2007/04/03 09:00
PHST- 2006/05/25 00:00 [received]
PHST- 2006/11/08 00:00 [revised]
PHST- 2006/12/25 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2007/07/11 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - S0925-4927(07)00008-X [pii]
AID - 10.1016/j.pscychresns.2006.12.018 [doi]
PST - ppublish
SO  - Psychiatry Res. 2007 May 15;155(1):29-44. doi: 10.1016/j.pscychresns.2006.12.018. 
      Epub 2007 Mar 30.