PMID- 17399814
OWN - NLM
STAT- MEDLINE
DCOM- 20080313
LR  - 20151119
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 124
IP  - 2
DP  - 2008 Feb 29
TI  - Simvastatin exerts its anti-inflammatory effect in hypercholesterolaemic patients 
      by decreasing the serum levels of monocyte chemoattractant protein-1.
PG  - 271-2
AB  - AIM: To assess the effect of simvastatin on serum levels of monocyte 
      chemoattractant protein-1 (MCP-1), interleukin-6, tumor necrosis factor-alpha, 
      macrophage colony stimulating factor, C-reactive protein and serum amyloid A in 
      hypercholesterolaemic patients without coronary heart disease. METHODS: Sixty 
      consecutive hypercholesterolaemic patients were randomly assigned in a 2:1 
      process to 40 mg of simvastatin daily (n=40) and to hypolipidaemic only diet 
      (n=20) for 3 months. Blood was taken at baseline and at the end of the study and 
      analysed for lipids and inflammatory markers. RESULTS: From the inflammatory 
      markers only MCP-1 was decreased significantly (217.4+/-48 versus 177+/-75 pg/ml, 
      p<0.001) after treatment with simvastatin and this reduction was independent of 
      lipid changes. CONCLUSION: Simvastatin significantly decreases only MCP-1 levels 
      in hypercholesterolaemic patients suggesting that this molecule is probably a 
      sensitive marker to detect the anti-inflammatory effect of simvastatin in blood.
FAU - Rallidis, Loukianos S
AU  - Rallidis LS
FAU - Hamodraka, Eftichia S
AU  - Hamodraka ES
FAU - Fountoulaki, Katerina
AU  - Fountoulaki K
FAU - Moustogiannis, Georgios
AU  - Moustogiannis G
FAU - Zolindaki, Maria G
AU  - Zolindaki MG
FAU - Kremastinos, Dimitrios T
AU  - Kremastinos DT
LA  - eng
PT  - Letter
PT  - Randomized Controlled Trial
DEP - 20070330
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
RN  - 0 (Amyloid)
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - AGG2FN16EV (Simvastatin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloid/blood/drug effects
MH  - Biomarkers/blood
MH  - C-Reactive Protein/drug effects/metabolism
MH  - Cardiovascular Diseases/prevention & control
MH  - Chemokine CCL2/blood/*drug effects
MH  - Cytokines/drug effects/metabolism
MH  - *Diet
MH  - Dose-Response Relationship, Drug
MH  - Drug Administration Schedule
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hypercholesterolemia/blood/diagnosis/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Probability
MH  - Reference Values
MH  - Risk Factors
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Simvastatin/*administration & dosage
MH  - Treatment Outcome
EDAT- 2007/04/03 09:00
MHDA- 2008/03/14 09:00
CRDT- 2007/04/03 09:00
PHST- 2006/11/09 00:00 [received]
PHST- 2006/12/31 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2008/03/14 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - S0167-5273(07)00373-7 [pii]
AID - 10.1016/j.ijcard.2006.12.059 [doi]
PST - ppublish
SO  - Int J Cardiol. 2008 Feb 29;124(2):271-2. doi: 10.1016/j.ijcard.2006.12.059. Epub 
      2007 Mar 30.