PMID- 17400056
OWN - NLM
STAT- MEDLINE
DCOM- 20071126
LR  - 20111117
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 68
IP  - 4
DP  - 2007 Apr
TI  - HLA-G complexes are observed on the cell surface.
PG  - 227-32
AB  - In the context of pregnancy, several immunomodulating mechanisms have developed 
      to regulate the maternal immune response to its semiallogeneic fetus. The 
      nonclassical major histocompatibility complex class I human leukocyte antigen-G 
      (HLA-G) was suggested to be involved in these mechanisms due to its unique 
      features and its immunosuppressive abilities. We have previously described the 
      presence of HLA-G complexes at the cell surface, which confer an efficient 
      natural killer inhibition through the leukocyte Ig-like receptor-1 (LIR-1). We 
      further demonstrated the presence of HLA-G free heavy chain (FHC) complexes, 
      which are not recognized and possibly interfere with LIR-1 and HLA-G interaction. 
      Here we expand our understanding of the nature of the complexes by demonstrating 
      that these complexes are observed mainly on the cell surface and not inside the 
      cell. We further determine that the HLA-G stability at the cell surface is not a 
      direct result of the presence of the HLA-G complexes. Finally, we suggest that 
      the FHC complexes are probably assembled from the conformed complexes present on 
      the cell surface.
FAU - Gonen-Gross, Tsufit
AU  - Gonen-Gross T
AD  - Lautenberg Center for General and Tumor Immunology, Hebrew University-Hadassah 
      Medical School, Jerusalem, Israel.
FAU - Mandelboim, Ofer
AU  - Mandelboim O
LA  - eng
PT  - Journal Article
DEP - 20061116
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA Antigens)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Cell Line, Transformed
MH  - Cell Line, Tumor
MH  - Cell Membrane/*immunology
MH  - HLA Antigens/*metabolism
MH  - HLA-G Antigens
MH  - Histocompatibility Antigens Class I/*metabolism
MH  - Humans
EDAT- 2007/04/03 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/04/03 09:00
PHST- 2006/06/21 00:00 [received]
PHST- 2006/10/03 00:00 [revised]
PHST- 2006/10/23 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - S0198-8859(06)00561-1 [pii]
AID - 10.1016/j.humimm.2006.10.013 [doi]
PST - ppublish
SO  - Hum Immunol. 2007 Apr;68(4):227-32. doi: 10.1016/j.humimm.2006.10.013. Epub 2006 
      Nov 16.