PMID- 17400189
OWN - NLM
STAT- MEDLINE
DCOM- 20070628
LR  - 20181201
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 356
IP  - 4
DP  - 2007 May 18
TI  - Effects of chromosomal variations on pharmacokinetic activity of zolpidem in 
      healthy volunteers: an array-based comparative genomic hybridization study.
PG  - 981-7
AB  - Zolpidem has been known as a very safe and effective hypnotic drug used to treat 
      a variety of patients with insomnia. Even though the same dose of the medicine is 
      administered to each patient, the blood level of zolpidem and the time required 
      to obtain peak concentration are not consistent among different people. We 
      evaluated the relationship between the peak concentrations of zolpidem and 
      chromosomal imbalances using a high-resolution genome-wide array-based 
      comparative genomic hybridization (CGH) in 16 healthy volunteers in order to 
      detect the genetic factors underlying the variations. The present study showed 
      that chromosomal losses were detected in the 4q35.2, 9p13.1 and 9p12 regions, and 
      those gains were indicated in the 2p14, 11q13.4 and 15q11.2 regions. The abnormal 
      regions were confirmed by fluorescence in situ hybridization (FISH) and real-time 
      PCR. It is suggested that array-CGH analysis may be used as a measure for 
      pharmacogenomic applications in the patients with insomnia and for further 
      exploration of candidate genomic regions implicated in sleep disturbances.
FAU - Moon, Ho-Jin
AU  - Moon HJ
AD  - Department of Pharmacology, College of Medicine, and Department of Psychiatry, 
      Our Lady of Mercy Hospital, The Catholic University of Korea, Seoul 137-701, 
      Republic of Korea.
FAU - Choi, Jin Soo
AU  - Choi JS
FAU - Park, E-Jin
AU  - Park EJ
FAU - Kang, Chin-Yang
AU  - Kang CY
FAU - Jeon, Yang-Whan
AU  - Jeon YW
FAU - Lee, Kweon-Haeng
AU  - Lee KH
FAU - Rha, Hyoung Kyun
AU  - Rha HK
FAU - Han, Sang-Ick
AU  - Han SI
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070326
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Pyridines)
RN  - 7K383OQI23 (Zolpidem)
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - Chromosomes, Human/*genetics
MH  - Genetic Variation/genetics
MH  - Genome, Human/genetics
MH  - Humans
MH  - In Situ Hybridization
MH  - Male
MH  - Metabolic Clearance Rate
MH  - Pyridines/*blood/*pharmacokinetics
MH  - Reference Values
MH  - Zolpidem
EDAT- 2007/04/03 09:00
MHDA- 2007/06/29 09:00
CRDT- 2007/04/03 09:00
PHST- 2007/03/03 00:00 [received]
PHST- 2007/03/15 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2007/06/29 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - S0006-291X(07)00570-0 [pii]
AID - 10.1016/j.bbrc.2007.03.089 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 May 18;356(4):981-7. doi: 
      10.1016/j.bbrc.2007.03.089. Epub 2007 Mar 26.