PMID- 17400268
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20111117
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 49
IP  - 8
DP  - 2007 Jun 15
TI  - Hematological and plasma biochemical responses of crucian carp (Carassius 
      auratus) to intraperitoneal injection of extracted microcystins with the possible 
      mechanisms of anemia.
PG  - 1150-7
AB  - Alterations in hematological indices such as decreases in blood cell counts 
      (RBC), hematocrit (Ht) and hemoglobin (Hb) concentrations are key symptoms of 
      anemia. However, few experiments were conducted to examine changes in 
      hematological indices of fish exposed to microcystins that are believed to be 
      fatal to circulatory systems of vertebrates. An acute toxicological experiment 
      was designed to study hematological changes of crucian carp injected 
      intraperitoneally (i.p.) with extracted microcystins at two doses, 50 and 200 
      microg MC-LReq kg(-1) body weight. After being i.p. injected with microcystins, 
      the fish exhibited behavioral abnormity. There were significant decreases in RBC 
      in the high-dose group, and in Ht and Hb concentrations in both dose groups, 
      while erythrocyte sedimentation rate (ESR) significantly increased, indicating 
      the appearance of normocytic anemia. There were no prominent changes in the three 
      red cell indices, mean corpuscular volume (MCV), mean corpuscular hemoglobin 
      (MCH), and mean corpuscular hemoglobin concentration (MCHC). Increases in blood 
      urea nitrogen (BUN) and creatinine (CR) in both dose groups suggest the 
      occurrence of kidney impairment. Alteration in blood indices was reversible at 
      the low dose group. Conclusively, anemia induced by kidney impairment was a key 
      factor to cause abnormity of swimming behaviors and high mortality of crucian 
      carp.
FAU - Zhang, Xuezhen
AU  - Zhang X
AD  - Fisheries College of Huazhong Agricultural University, Key Laboratory of 
      Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, 
      Wuhan 430070, PR China.
FAU - Xie, Ping
AU  - Xie P
FAU - Li, Dapeng
AU  - Li D
FAU - Shi, Zechao
AU  - Shi Z
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070225
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Hemoglobins)
RN  - 0 (Microcystins)
SB  - IM
MH  - Analysis of Variance
MH  - Anemia/blood/chemically induced/*veterinary
MH  - Animals
MH  - Blood Cell Count/veterinary
MH  - China
MH  - Cyanobacteria/*chemistry
MH  - Dose-Response Relationship, Drug
MH  - Fish Diseases/*blood/*chemically induced
MH  - *Goldfish
MH  - Hematocrit/veterinary
MH  - Hemoglobins/analysis
MH  - Injections, Intraperitoneal
MH  - Kidney/pathology
MH  - Microcystins/administration & dosage/*toxicity
MH  - Toxicity Tests, Acute/methods
EDAT- 2007/04/03 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/04/03 09:00
PHST- 2006/11/13 00:00 [received]
PHST- 2007/02/07 00:00 [revised]
PHST- 2007/02/07 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - S0041-0101(07)00062-1 [pii]
AID - 10.1016/j.toxicon.2007.02.009 [doi]
PST - ppublish
SO  - Toxicon. 2007 Jun 15;49(8):1150-7. doi: 10.1016/j.toxicon.2007.02.009. Epub 2007 
      Feb 25.