PMID- 1740062
OWN - NLM
STAT- MEDLINE
DCOM- 19920324
LR  - 20181130
IS  - 0010-8901 (Print)
IS  - 0010-8901 (Linking)
VI  - 82
IP  - 1
DP  - 1992 Jan
TI  - Serum concentrations of cefepime (BMY-28142), a broad-spectrum cephalosporin, in 
      dogs.
PG  - 69-77
AB  - Serum concentrations of cefepime (BMY-28142) were determined for four dosing 
      regimes, 10 mg/kg or 20 mg/kg, given as single subcutaneous (SC) or intramuscular 
      injections (IM) to dogs. Serial serum samples were analyzed for the presence of 
      cefepime by high-performance liquid chromatography. In experiment 1, the overall 
      mean (+/- SEM) serum concentration (for a 12-hour period) after a dose of 20 
      mg/kg for SC and IM routes (4.9 +/- 0.74 micrograms/ml and 5.5 +/- 0.63 
      micrograms/ml, respectively) was twice that for the 10 mg/kg dose given either SC 
      or IM (2.2 +/- 0.31 micrograms/ml and 2.8 +/- 0.47 micrograms/ml, respectively). 
      There was no significant difference (p greater than 0.05) in mean serum 
      concentrations for SC and IM routes of administration at the same dosage. In 
      subsequent experiments, 5 doses of cefepime (20 mg/kg) were administered IM at 
      12-hour (experiment 2) or 24-hour (experiment 3) intervals. The mean (+/- SEM) 
      peak serum concentration was 12.1 +/- 1.59 micrograms/ml, 2 hours after the 2nd 
      injection in experiment 2. In experiment 3, the mean (+/- SEM) peak serum 
      concentration was 10.9 +/- 1.34 micrograms/ml, 4 hours after the 1st injection. 
      Mean trough concentrations in experiment 2 were greater than or equal to 0.5 
      microgram/ml and less than or equal to 0.5 in experiment 3. Multiple IM doses 
      produced transient edema at the injection site and mild lameness in all dogs. 
      Cefepime was highly active against single canine isolates of Staphylococcus 
      intermedius, Pseudomonas aeruginosa and Escherichia coli, with minimum inhibitory 
      concentrations of 0.125 microgram/ml, 1 microgram/ml and 0.3 microgram/ml, 
      respectively.
FAU - Stampley, A R
AU  - Stampley AR
AD  - Department of Small Animal Clinical Sciences, College of Veterinary Medicine, 
      JHMHC, University of Florida, Gainesville 32610-0126.
FAU - Brown, M P
AU  - Brown MP
FAU - Gronwall, R R
AU  - Gronwall RR
FAU - Castro, L
AU  - Castro L
FAU - Stone, H W
AU  - Stone HW
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cornell Vet
JT  - The Cornell veterinarian
JID - 0074245
RN  - 0 (Cephalosporins)
RN  - 807PW4VQE3 (Cefepime)
SB  - IM
MH  - Animals
MH  - Cefepime
MH  - Cephalosporins/administration & dosage/blood/*pharmacokinetics
MH  - Chromatography, High Pressure Liquid
MH  - Dogs/blood/*metabolism
MH  - Female
MH  - Injections, Intramuscular/veterinary
MH  - Injections, Subcutaneous/veterinary
MH  - Male
EDAT- 1992/01/01 00:00
MHDA- 1992/01/01 00:01
CRDT- 1992/01/01 00:00
PHST- 1992/01/01 00:00 [pubmed]
PHST- 1992/01/01 00:01 [medline]
PHST- 1992/01/01 00:00 [entrez]
PST - ppublish
SO  - Cornell Vet. 1992 Jan;82(1):69-77.