PMID- 17401680
OWN - NLM
STAT- MEDLINE
DCOM- 20070917
LR  - 20220716
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 32
IP  - 7
DP  - 2007 Jul
TI  - Triptolide upregulates NGF synthesis in rat astrocyte cultures.
PG  - 1113-9
AB  - Triptolide (T10), an extract from the traditional Chinese herb, Tripterygium 
      wilfordii Hook F (TWHF), has been shown to attenuate the rotational behavior 
      induced by D: -amphetamine and prevent the loss of dopaminergic neurons in the 
      substantia nigra in rat models of Parkinson's disease. To examine if the 
      neuroprotective effect is mediated by its stimulation of production of 
      neurotrophic factors from astrocytes, we investigated the effect of T10 on 
      synthesis and release of nerve growth factor (NGF), brain-derived neurotrophic 
      factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) in rat 
      astrocyte cultures. T10 did not affect the synthesis and release of either BDNF 
      or GDNF. However, it significantly increased NGF mRNA expression. It also 
      increased both intracellular NGF and NGF level in culture medium. These results 
      indicate that the neuroprotective effect of T10 might be mediated, at least in 
      part, via a stimulation of the production and release of NGF in astrocytes.
FAU - Xue, Bing
AU  - Xue B
AD  - Department of Neurobiology, Neuroscience Research Institute, Peking University, 
      Beijing, 100083, People's Republic of China.
FAU - Jiao, Jian
AU  - Jiao J
FAU - Zhang, Lei
AU  - Zhang L
FAU - Li, Kai-Rong
AU  - Li KR
FAU - Gong, Yun-Tao
AU  - Gong YT
FAU - Xie, Jun-Xia
AU  - Xie JX
FAU - Wang, Xiao-Min
AU  - Wang XM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070331
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Diterpenes)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Epoxy Compounds)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Immunosuppressive Agents)
RN  - 0 (Phenanthrenes)
RN  - 19ALD1S53J (triptolide)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Astrocytes/cytology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Cells, Cultured
MH  - Diterpenes/*metabolism
MH  - Drugs, Chinese Herbal/metabolism
MH  - Epoxy Compounds/metabolism
MH  - Glial Cell Line-Derived Neurotrophic Factor/metabolism
MH  - Immunosuppressive Agents/*metabolism
MH  - Medicine, Chinese Traditional
MH  - Nerve Growth Factor/*biosynthesis
MH  - Phenanthrenes/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2007/04/03 09:00
MHDA- 2007/09/18 09:00
CRDT- 2007/04/03 09:00
PHST- 2006/11/13 00:00 [received]
PHST- 2006/12/12 00:00 [accepted]
PHST- 2007/04/03 09:00 [pubmed]
PHST- 2007/09/18 09:00 [medline]
PHST- 2007/04/03 09:00 [entrez]
AID - 10.1007/s11064-006-9253-1 [doi]
PST - ppublish
SO  - Neurochem Res. 2007 Jul;32(7):1113-9. doi: 10.1007/s11064-006-9253-1. Epub 2007 
      Mar 31.