PMID- 17403953
OWN - NLM
STAT- MEDLINE
DCOM- 20071107
LR  - 20181113
IS  - 1469-0756 (Electronic)
IS  - 0032-5473 (Print)
IS  - 0032-5473 (Linking)
VI  - 83
IP  - 978
DP  - 2007 Apr
TI  - Tako-tsubo syndrome on the rise: a review of the current literature.
PG  - 261-4
AB  - Tako-tsubo syndrome (TTS) or stress-related acute reversible ventricular apical 
      dysfunction is an emerging but seemingly under-recognised cardiomyopathy 
      mimicking acute ST elevation myocardial infarction (STEMI) without concomitant 
      epicardial coronary artery disease. Severe emotional stress is the most common 
      trigger for this syndrome in the published series, but it can also be 
      precipitated by severe intercurrent medical illness. Precise epidemiological data 
      are not yet available, although TTS most commonly affects elderly women. The 
      exact cause of this syndrome is undetermined, but proposed mechanisms include 
      epicardial coronary artery vasospasm, impaired multivessel coronary 
      microcirculation, calcium overload with direct myocyte damage and disrupted fatty 
      acid metabolism with prolonged myocardial stunning. The time course of 
      electrocardiographic changes is very similar to that of an acute STEMI due to an 
      acute occlusion of the left anterior descending coronary artery. The left 
      ventricular dysfunction typically displays an akinetic apical half of the left or 
      both ventricles with hyperkinetic basal segments, although a variant with apical 
      sparing has also been described recently. The ventricular dysfunction usually 
      resolves within weeks and carries a generally favourable prognosis.
FAU - Buchholz, Stefan
AU  - Buchholz S
AD  - Department of Cardiology, Manly District General Hospital, Darley Road, Manly, 
      NSW 2095, Australia. stefanbuchholz@hotmail.com
FAU - Rudan, George
AU  - Rudan G
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (Fatty Acids)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Aged
MH  - Calcium/metabolism
MH  - Coronary Disease/complications
MH  - Coronary Vasospasm/complications
MH  - Electrocardiography
MH  - Fatty Acids/metabolism
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Myocardial Stunning/complications
MH  - Stress, Psychological/*complications/epidemiology
MH  - Syndrome
MH  - Ventricular Dysfunction, Left/epidemiology/*psychology
PMC - PMC2600040
COIS- Competing interests: None.
EDAT- 2007/04/04 09:00
MHDA- 2007/11/08 09:00
PMCR- 2010/04/01
CRDT- 2007/04/04 09:00
PHST- 2007/04/04 09:00 [pubmed]
PHST- 2007/11/08 09:00 [medline]
PHST- 2007/04/04 09:00 [entrez]
PHST- 2010/04/01 00:00 [pmc-release]
AID - 83/978/261 [pii]
AID - pj52423 [pii]
AID - 10.1136/pgmj.2006.052423 [doi]
PST - ppublish
SO  - Postgrad Med J. 2007 Apr;83(978):261-4. doi: 10.1136/pgmj.2006.052423.