PMID- 17405156
OWN - NLM
STAT- MEDLINE
DCOM- 20080212
LR  - 20171116
IS  - 1545-5017 (Electronic)
IS  - 1545-5009 (Linking)
VI  - 50
IP  - 3
DP  - 2008 Mar
TI  - Complex chromosome 8;21 translocation with associated hyperdiploidy in acute 
      myeloid leukemia (FAB-M2).
PG  - 651-4
AB  - We present a case of acute myeloblastic leukemia (AML-M2) with a complex t(8;21) 
      translocation and additional acquired chromosomes yielding a hyperdiploid 
      karyotype. AML1/ETO transcript was observed by reverse transcription-polymerase 
      chain reaction. Fluorescence in situ hybridization (FISH), spectral karyotyping 
      (SKY), and comparative genomic hybridization (CGH) were performed to further 
      identify the chromosomes observed by G banding. The patient was treated according 
      to our current protocol for AML. He remains in complete remission +11 months from 
      diagnosis. Further follow-up of this patient and the analysis of a larger number 
      of children are needed to define whether the gains of the specific extra 
      chromosomes modify the good prognosis that t(8;21) confers to this subgroup of 
      AML.
CI  - (c) 2007 Wiley-Liss, Inc.
FAU - Corral, Maria del Pilar
AU  - Corral Mdel P
AD  - Cytogenetics Laboratory, Department of Genetics, Hospital de Pediatria SAMIC 
      "Prof. Dr. J P Garrahan", Buenos Aires, Argentina.
FAU - Villa, Olaya
AU  - Villa O
FAU - Alfaro, Elizabeth M
AU  - Alfaro EM
FAU - Alonso, Cristina N
AU  - Alonso CN
FAU - Baro, Cristina
AU  - Baro C
FAU - Felice, Maria S
AU  - Felice MS
FAU - Rossi, Jorge
AU  - Rossi J
FAU - Sole, Francesc
AU  - Sole F
FAU - Gallego, Marta S
AU  - Gallego MS
LA  - eng
PT  - Case Reports
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Pediatr Blood Cancer
JT  - Pediatric blood & cancer
JID - 101186624
RN  - 0 (AML1-ETO fusion protein, human)
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (RUNX1 Translocation Partner 1 Protein)
RN  - 04079A1RDZ (Cytarabine)
RN  - 6PLQ3CP4P3 (Etoposide)
RN  - ZRP63D75JW (Idarubicin)
RN  - ICE protocol 4
SB  - IM
MH  - *Aneuploidy
MH  - Antineoplastic Combined Chemotherapy Protocols/administration & 
      dosage/therapeutic use
MH  - Child
MH  - Chromosomes, Human, Pair 21/genetics/*ultrastructure
MH  - Chromosomes, Human, Pair 8/genetics/*ultrastructure
MH  - Core Binding Factor Alpha 2 Subunit/*genetics
MH  - Cytarabine/administration & dosage
MH  - Cytogenetic Analysis
MH  - Etoposide/administration & dosage
MH  - Humans
MH  - Idarubicin/administration & dosage
MH  - Leukemia, Myeloid, Acute/drug therapy/*genetics
MH  - Male
MH  - Nucleic Acid Hybridization
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Polymerase Chain Reaction
MH  - RUNX1 Translocation Partner 1 Protein
MH  - *Translocation, Genetic
EDAT- 2007/04/04 09:00
MHDA- 2008/02/13 09:00
CRDT- 2007/04/04 09:00
PHST- 2007/04/04 09:00 [pubmed]
PHST- 2008/02/13 09:00 [medline]
PHST- 2007/04/04 09:00 [entrez]
AID - 10.1002/pbc.21192 [doi]
PST - ppublish
SO  - Pediatr Blood Cancer. 2008 Mar;50(3):651-4. doi: 10.1002/pbc.21192.