PMID- 17405297
OWN - NLM
STAT- MEDLINE
DCOM- 20070605
LR  - 20131121
IS  - 1426-9686 (Print)
IS  - 1426-9686 (Linking)
VI  - 21
IP  - 126
DP  - 2006 Dec
TI  - [Beneficial actions of lipoic acid in cerebral cortex homogenates in rats during 
      lipopolysaccharide-induced oxidative stress].
PG  - 554-7
AB  - The aim of his study was to assess the effect of lipoic acid (LA) on lipid 
      peroxidation, hydrogen peroxide(H2O2) concentration, sulfhryl group (-SH) 
      contents in the cerebral cortex homogenates in the early stage of oxidative 
      stress. MATERIALS AND METHODS: Experiments were performed on male rats Wistar 
      300-320 g body weight. The animals were divided into four groups consisting of 
      eight animals each. Control group received saline alone into the tail vein 
      (i.v.). The second group received LA (60 mg/kg b.w., i.v.). The third group 
      received LPS (30 mg/kg b.w., i.v.). The fourth group received LPS (30 mg/kg b.w., 
      i.v.) and after 0.5 h received LA (60 mg/kg b.w., i.v.). In the homogenates from 
      cerebral cortex were measured thiobarbituric acid reactants (TBARS) as indicator 
      lipid peroxidation, H2O2 concentration and -SH groups contents. RESULTS: The 
      administration of LA after LPS-induced oxidative stress caused a significant 
      decrease in TBARS and H2O2 concentration 5.38 + 0.084 micromol and 0.028 + 0.002 
      micromol, respectively) compared with the group treated with LPS (6.96 + 0.063 
      micromol and 0.198 + 0.003 micromol, respectively). Treatment of LPS-injected 
      rats with LA caused increase in -SH groups (p < 0.05). CONCLUSION: The early 
      administration of LA a significant suppressed symptoms of oxidative 
      stress-induced LPS, expressed as a decrease in lipid peroxidation process, H2O2 
      generation and increase in concentration of protein containing thiol groups in 
      the cerebral cortex homogenates.
FAU - Goraca, Anna
AU  - Goraca A
AD  - Department of Experimental and Clinical Physiology, Medical University of Lodz, 
      Poland. agoraca@zdn.am.lodz.pl
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Korzystne dzialanie kwasu liponowego w homogenatach kory mozgowej szczura w 
      czasie stresu oksydacyjnego wywolanego lipopolisacharydem.
PL  - Poland
TA  - Pol Merkur Lekarski
JT  - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego
JID - 9705469
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Sulfhydryl Compounds)
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - BBX060AN9V (Hydrogen Peroxide)
SB  - IM
MH  - Animals
MH  - Cerebral Cortex/chemistry/*metabolism
MH  - Hydrogen Peroxide/analysis/metabolism
MH  - Lipid Peroxidation/*drug effects
MH  - Lipopolysaccharides/antagonists & inhibitors
MH  - Male
MH  - Oxidative Stress/drug effects/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Sulfhydryl Compounds/analysis/metabolism
MH  - Thiobarbituric Acid Reactive Substances/*analysis/metabolism
MH  - Thioctic Acid/*pharmacology
EDAT- 2007/04/05 09:00
MHDA- 2007/06/06 09:00
CRDT- 2007/04/05 09:00
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2007/06/06 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
PST - ppublish
SO  - Pol Merkur Lekarski. 2006 Dec;21(126):554-7.