PMID- 17406982
OWN - NLM
STAT- MEDLINE
DCOM- 20071203
LR  - 20181113
IS  - 0364-3190 (Print)
IS  - 0364-3190 (Linking)
VI  - 32
IP  - 8
DP  - 2007 Aug
TI  - Effect of electroacupuncture on neurotrophin expression in cat spinal cord after 
      partial dorsal rhizotomy.
PG  - 1415-22
AB  - Neuroplasticity of the spinal cord following electroacupuncture (EA) has been 
      demonstrated although little is known about the possible underlying mechanism. 
      This study evaluated the effect of EA on expression of neurotrophins in the 
      lamina II of the spinal cord, in cats subjected to dorsal rhizotomy. Cats 
      received bilateral removal of L1-L5 and L7-S2 dorsal root ganglia (DRG, L6 DRG 
      spared) and unilateral EA. They were sacrificed 7 days after surgery, and the L6 
      spinal segment removed and processed by immunohistochemistry and in situ 
      hybridization histochemistry, to demonstrate the expression of neurotrophins. 
      Significantly greater numbers of nerve growth factor (NGF) and neurotrophin-3 
      (NT-3) positive neurons, brain-derived neurotrophic factor (BDNF) immunoreactive 
      varicosities and NT-3 positive neurons and glial cells were observed in lamina II 
      on the acupunctured (left) side, compared to the non-acupunctured, contralateral 
      side. Greater number of neurons expressing NGF mRNA was also observed on the 
      acupunctured side. No signal for mRNA to BDNF and NT-3 was detected. The above 
      findings demonstrate that EA can increase the expression of endogenous NGF at 
      both the mRNA and protein level, and BDNF and NT-3 at the protein level. It is 
      postulated that EA may promote the plasticity of the spinal cord by inducing 
      increased expression of neurotrophins.
FAU - Wang, Ting-Hua
AU  - Wang TH
AD  - Department of Histology and Neurobiology, College of Preclinical Forensic 
      Medicine, Sichuan University, Chengdu, China. tinghua_neuron@263.net
FAU - Wang, Xu-Yang
AU  - Wang XY
FAU - Li, Xiao-Li
AU  - Li XL
FAU - Chen, Hong-Ming
AU  - Chen HM
FAU - Wu, Liang-Fang
AU  - Wu LF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070404
PL  - United States
TA  - Neurochem Res
JT  - Neurochemical research
JID - 7613461
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cats
MH  - *Electroacupuncture
MH  - In Situ Hybridization
MH  - Male
MH  - Nerve Growth Factor/genetics/*metabolism
MH  - Neuronal Plasticity/physiology
MH  - Neurons/cytology/metabolism
MH  - Neurotrophin 3/*metabolism
MH  - *Rhizotomy
MH  - Spinal Cord/cytology/*metabolism/pathology
EDAT- 2007/04/05 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/04/05 09:00
PHST- 2006/12/05 00:00 [received]
PHST- 2007/03/01 00:00 [accepted]
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
AID - 10.1007/s11064-007-9326-9 [doi]
PST - ppublish
SO  - Neurochem Res. 2007 Aug;32(8):1415-22. doi: 10.1007/s11064-007-9326-9. Epub 2007 
      Apr 4.