PMID- 17407086
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 24
IP  - 2
DP  - 2007 Apr
TI  - [Study on relationship between polymorphism sites of TIM4 and allergic asthma in 
      the population of Han nationality from Hubei province of China].
PG  - 213-6
AB  - OBJECTIVE: To investigate two single nucleotide polymorphism sites of T cell 
      immunoglobulin domain and mucin domain protein-4 (TIM4) and to detect their 
      relationship with allergic asthma in a population of Hans from Hubei province of 
      China. METHODS: The polymorphisms (8570G > A and 11515C > A) were detected with 
      polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 
      145 cases of allergic asthma and 130 healthy controls. The genotype and allele 
      frequencies were calculated and analyzed. RESULTS: The genotype frequencies of 
      GG, GA and AA in 8570G > A polymorphism were 0.985, 0.015 and 0 respectively in 
      the healthy population and 0.931, 0.069 and 0 respectively in the allergic asthma 
      population. There was significant difference in genotype and allele frequencies 
      between the allergic asthma patients and control subjects (P=0. 030, P=0.032). 
      The polymorphism of 11515C>o A was not detected. CONCLUSION: The polymorphism of 
      8570G > A in TIM4 may be associated with allergic asthma in the population of Han 
      nationality from Hubei province of China.
FAU - Xia, Yi-ping
AU  - Xia YP
AD  - Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University 
      of Science and Technology, Wuhan, Hubei, 430022 PR China.
FAU - Cui, Tian-pen
AU  - Cui TP
FAU - Wu, Jian-min
AU  - Wu JM
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - 0 (Membrane Proteins)
RN  - 0 (TIMD4 protein, human)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People/genetics
MH  - Asthma/ethnology/*genetics
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Infant
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Young Adult
EDAT- 2007/04/05 09:00
MHDA- 2009/03/28 09:00
CRDT- 2007/04/05 09:00
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
AID - 940624048 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Apr;24(2):213-6.