PMID- 17407087
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20220311
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 24
IP  - 2
DP  - 2007 Apr
TI  - [Meiotic segregation results of male reciprocal chromosome translocations].
PG  - 217-20
AB  - OBJECTIVE: To analyze the meiotic segregation results of male reciprocal 
      chromosome translocation by fluorescence in situ hybridization (FISH). METHODS: 
      Multi-color FISH using 3 combined probes located in any 3 chromosome segments on 
      both sides of two breakpoints was performed on the de-condensed sperm head to 
      analyze the sperm chromosomal contents and segregation patterns. RESULTS: Four 
      male reciprocal translocation carriers were included in the study, with the 
      karyotypes of 46, XY, t(2;18) (p16; q23); 46, XY, t(4;6) (q34;q21); 46, XY, 
      t(8;13) (q23;q21) and 46, XY, t(4;5) (4q31;5q13), respectively. The results 
      showed that 4 carriers had different proportions of various segregated 
      spermatozoa. The spermatozoa of alternate, adjacent-1, adjacent-2, 3:1, 
      non-disjunction in meiosis II, and 4:0 or diploidy accounted for 27.1%-49.4%, 
      26.9%-37.6%, 2.7%-15.7%, 8.6%-32.7%, 0.2%-1.9%, and 0.1%-0.4%, respectively. 
      CONCLUSION: For each-reciprocal translocation carrier seems to have a particular 
      meiotic segregation results, FISH analysis on sperm head should be done for each 
      carrier in order to provide an accurate genetic counseling.
FAU - Huang, Xue-feng
AU  - Huang XF
AD  - Reproductive Medicine Center, First Affiliated Hospital, Wenzhou Medical College, 
      Wenzhou, Zhejiang, 325000 PR China. xfhuang@hosp1.ac.cn
FAU - Xiao, Shi-quan
AU  - Xiao SQ
FAU - Fei, Qian-jin
AU  - Fei QJ
FAU - Zhang, Wei
AU  - Zhang W
FAU - Zhang, Li-ya
AU  - Zhang LY
FAU - Yang, Xu
AU  - Yang X
FAU - Ye, Bi-lv
AU  - Ye BL
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Chromosome Breakage
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Meiosis/*genetics
MH  - Spermatozoa/metabolism
MH  - Translocation, Genetic/*genetics
EDAT- 2007/04/05 09:00
MHDA- 2009/03/28 09:00
CRDT- 2007/04/05 09:00
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
AID - 940624049 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Apr;24(2):217-20.