PMID- 17407231
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20221207
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 34
IP  - 4
DP  - 2007 Apr
TI  - Monocyte chemoattractant protein-1: plasma concentrations and A(-2518)G promoter 
      polymorphism of its gene in systemic lupus erythematosus.
PG  - 740-6
AB  - OBJECTIVE: To determine (1) whether the A(-2518)G polymorphism of CCL-2, the gene 
      encoding monocyte chemoattractant protein-1 (MCP-1), is associated with disease, 
      MCP-1 concentration, nephritis, or coronary artery calcification (CAC) in 
      systemic lupus erythematosus (SLE); and (2) whether MCP-1 and homocysteine (Hcy) 
      concentrations are correlated. METHODS: Statistical tests were applied to 
      determine the relationships between CCL-2 A(-2518)G genotypes, plasma MCP-1 
      concentrations, and clinical variables in Caucasian and African American patients 
      with SLE and controls. RESULTS: The CCL-2 (-2518)G allele was not significantly 
      associated with SLE in the whole study sample (p = 0.07). Among Caucasians, but 
      not African Americans, G allele carriers had significantly increased risk of SLE 
      (OR 4.2, 95% CI 1.8-9.6, p < 0.0001). Genotype was not associated with nephritis, 
      CAC, or MCP-1 concentrations when all patients or all controls were considered; 
      however, among recently diagnosed patients, G allele carriers had significantly 
      higher MCP-1 concentrations than AA homozygotes (p = 0.02). SLE patients had 
      higher MCP-1 concentrations than controls (p < 0.0001), African American patients 
      had higher concentrations than Caucasian patients (p = 0.006), and patients with 
      nephritis had higher concentrations than those without nephritis (p = 0.02). 
      Although not associated with CAC, MCP-1 concentrations were significantly 
      positively correlated with Hcy. CONCLUSION. CCL-2 A(-2518)G genotype is a 
      significant risk factor for SLE among Caucasians but not African Americans, 
      suggesting that genetically mandated differences in MCP-1 expression contribute 
      to SLE etiology in the former. The positive correlation between MCP-1 and Hcy 
      concentrations is consistent with the hypothesis that active inflammation and 
      hyperhomocysteinemia are etiologically linked.
FAU - Brown, Karen S
AU  - Brown KS
AD  - Department of Pharmacology and Center for Pharmacogenetics, University of 
      Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.
FAU - Nackos, Eleni
AU  - Nackos E
FAU - Morthala, Suneetha
AU  - Morthala S
FAU - Jensen, Liselotte E
AU  - Jensen LE
FAU - Whitehead, Alexander S
AU  - Whitehead AS
FAU - Von Feldt, Joan M
AU  - Von Feldt JM
LA  - eng
GR  - AR47663/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Black or African American
MH  - Calcinosis/immunology
MH  - Case-Control Studies
MH  - Chemokine CCL2/blood/*genetics
MH  - Coronary Vessels/pathology
MH  - Female
MH  - Genetic Predisposition to Disease/genetics
MH  - Homocysteine/*blood
MH  - Humans
MH  - Lupus Erythematosus, Systemic/*blood/ethnology/*genetics
MH  - Middle Aged
MH  - Nephritis/blood/genetics/immunology
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - White People
EDAT- 2007/04/05 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/05 09:00
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
AID - 0315162X-34-740 [pii]
PST - ppublish
SO  - J Rheumatol. 2007 Apr;34(4):740-6.