PMID- 17407809
OWN - NLM
STAT- MEDLINE
DCOM- 20070807
LR  - 20131121
IS  - 0939-6411 (Print)
IS  - 0939-6411 (Linking)
VI  - 66
IP  - 3
DP  - 2007 Jun
TI  - Solid lipid microparticles containing the sunscreen agent, 
      octyl-dimethylaminobenzoate: effect of the vehicle.
PG  - 483-7
AB  - Solid lipid microparticles (SLMs) loaded with the sunscreen agent, 
      octyl-dimethylaminobenzoate (ODAB), were prepared in order to achieve enhanced 
      sunscreen photostability. The microparticles were produced by the melt dispersion 
      technique using glyceryl behenate as lipidic material and poloxamer 188 as the 
      emulsifier. The obtained SLMs showed proper features in terms of morphology, size 
      distribution (1.67-15.81 microm) and ODAB loading (16.15+/-0.11%, w/w). The 
      sunscreen release from the SLMs was slower than its dissolution rate and the 
      photodecomposition of ODAB was markedly decreased (>51.3%) by encapsulation into 
      the lipid microparticles. The efficacy of the SLM carrier system was also 
      evaluated after their introduction in model topical formulations (i.e., hydrogel 
      and oil-in-water emulsion). Further in vitro release measurements, performed 
      using Franz diffusion cells with polycarbonate membranes, indicated that the 
      retention capacity of the microparticles was lost after their incorporation into 
      the emulsion, whereas it was retained in the hydrogel. Moreover, the SLMs 
      achieved a reduction of the sunscreen photodegradation in the hydrogel vehicle 
      (the ODAB loss decreased from 87.4% to 59.1%), whereas no significant 
      photoprotective effect was observed in the emulsion. Therefore, the efficacy of 
      the ODAB-loaded SLMs was markedly affected by the vehicle.
FAU - Tursilli, Rosanna
AU  - Tursilli R
AD  - Department of Pharmaceutical Sciences, University of Ferrara, Italy.
FAU - Piel, Geraldine
AU  - Piel G
FAU - Delattre, Luc
AU  - Delattre L
FAU - Scalia, Santo
AU  - Scalia S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070228
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Fatty Acids)
RN  - 0 (Pharmaceutical Vehicles)
RN  - 0 (Sunscreening Agents)
RN  - 0 (octyl-dimethylaminobenzoate)
RN  - 106392-12-5 (Poloxamer)
RN  - 18641-57-1 (glyceryl behenate)
RN  - A49L8E13FD (p-Dimethylaminoazobenzene)
SB  - IM
MH  - Drug Stability
MH  - Fatty Acids/*administration & dosage
MH  - Pharmaceutical Vehicles
MH  - Photolysis
MH  - Poloxamer/*administration & dosage
MH  - Sunscreening Agents/*administration & dosage/chemistry
MH  - p-Dimethylaminoazobenzene/administration & dosage/*analogs & 
      derivatives/chemistry
EDAT- 2007/04/05 09:00
MHDA- 2007/08/08 09:00
CRDT- 2007/04/05 09:00
PHST- 2006/11/07 00:00 [received]
PHST- 2007/02/14 00:00 [revised]
PHST- 2007/02/21 00:00 [accepted]
PHST- 2007/04/05 09:00 [pubmed]
PHST- 2007/08/08 09:00 [medline]
PHST- 2007/04/05 09:00 [entrez]
AID - S0939-6411(07)00079-3 [pii]
AID - 10.1016/j.ejpb.2007.02.017 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2007 Jun;66(3):483-7. doi: 10.1016/j.ejpb.2007.02.017. Epub 
      2007 Feb 28.