PMID- 17408888
OWN - NLM
STAT- MEDLINE
DCOM- 20070912
LR  - 20131121
IS  - 0378-1135 (Print)
IS  - 0378-1135 (Linking)
VI  - 123
IP  - 1-3
DP  - 2007 Jul 20
TI  - Antiapoptotic activity of bovine herpesvirus type-1 (BHV-1) UL14 protein.
PG  - 210-6
AB  - Viruses have evolved different strategies to interfere with apoptotic pathways in 
      order to halt cellular responses to infection. One previous study showed that 
      transient transfection of bovine herpesvirus type-1 (BHV-1) UL14 protein is 
      efficient in protecting Madin Darby kidney (MDBK) and human chronic myelogenous 
      leukemia (K562) cells from sorbitol-induced apoptosis. This protein corresponds 
      to a putative protein of BHV-1, which shares aminoacid sequence with a part of 
      the peptide-binding domain conserved in human heat shock protein (HSP70) family. 
      The pBK-CMV-UL14 plasmid transfected MDBK cells treated with sorbitol did not 
      show caspase-3 and caspase-9 activation with respect to non-transfected MDBK 
      cells (UL14 negative). Furthermore, we report that the expression of the full 
      length sequence of BHV-1 UL14 is evident after 7 h of infection of BHV-1 on MDBK 
      cells which were then treated with sorbitol. These results indicate that UL14 
      gene product has important implications to enhance cell survival in response to 
      apoptotic stimuli.
FAU - De Martino, L
AU  - De Martino L
AD  - Department of Pathology and Animal Health, Infectious Diseases, Medicine 
      Veterinary School, University of Naples Federico II, Via F. Delpino 1, 80137 
      Naples, Italy. luisa.demartino@unina.it
FAU - Marfe, G
AU  - Marfe G
FAU - Consalvo, M Irno
AU  - Consalvo MI
FAU - Di Stefano, C
AU  - Di Stefano C
FAU - Pagnini, U
AU  - Pagnini U
FAU - Sinibaldi-Salimei, P
AU  - Sinibaldi-Salimei P
LA  - eng
PT  - Journal Article
DEP - 20070228
PL  - Netherlands
TA  - Vet Microbiol
JT  - Veterinary microbiology
JID - 7705469
RN  - 0 (UL14 protein, Human herpesvirus 1)
RN  - 0 (Viral Proteins)
RN  - 506T60A25R (Sorbitol)
RN  - EC 3.4.22.- (Caspase 3)
RN  - EC 3.4.22.- (Caspase 9)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Caspase 3/metabolism
MH  - Caspase 9/metabolism
MH  - Cattle
MH  - Cell Line
MH  - Gene Expression Regulation, Viral
MH  - Herpesvirus 1, Bovine/*metabolism
MH  - Humans
MH  - Sorbitol
MH  - Viral Proteins/genetics/*metabolism
EDAT- 2007/04/06 09:00
MHDA- 2007/09/13 09:00
CRDT- 2007/04/06 09:00
PHST- 2006/12/28 00:00 [received]
PHST- 2007/02/14 00:00 [revised]
PHST- 2007/02/21 00:00 [accepted]
PHST- 2007/04/06 09:00 [pubmed]
PHST- 2007/09/13 09:00 [medline]
PHST- 2007/04/06 09:00 [entrez]
AID - S0378-1135(07)00107-1 [pii]
AID - 10.1016/j.vetmic.2007.02.026 [doi]
PST - ppublish
SO  - Vet Microbiol. 2007 Jul 20;123(1-3):210-6. doi: 10.1016/j.vetmic.2007.02.026. 
      Epub 2007 Feb 28.