PMID- 17409176
OWN - NLM
STAT- MEDLINE
DCOM- 20070710
LR  - 20220309
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 97
IP  - 4
DP  - 2007 Apr
TI  - Interval coding. I. Burst interspike intervals as indicators of stimulus 
      intensity.
PG  - 2731-43
AB  - Short interspike intervals such as those that occur during burst firing are 
      hypothesized to be distinct features of the neural code. Although a number of 
      correlations between the occurrence of burst events and aspects of the stimulus 
      have been identified, the relationship between burst characteristics and 
      information transfer is uncertain. Pyramidal cells in the electrosensory lobe of 
      the weakly electric fish, Apteronotus leptorhynchus, respond to dynamic broadband 
      electrosensory stimuli with bursts and isolated spikes. In the present study, we 
      mimic synaptic input during sensory stimulation by direct stimulation of 
      electrosensory pyramidal cells with broadband current in vitro. The pyramidal 
      cells respond to this stimulus with burst interspike intervals (ISIs) that are 
      reliably and precisely correlated with the intensity of stimulus upstrokes. We 
      found burst ISIs must differ by a minimum of 2 ms to discriminate, with low 
      error, differences in stimulus intensity. Based on these results, we define and 
      quantify a candidate interval code for the processing of sensory input. Finally, 
      we demonstrate that interval coding is restricted to short ISIs such as those 
      generated in burst events and that the proposed interval code is distinct from 
      rate and timing codes.
FAU - Oswald, Anne-Marie M
AU  - Oswald AM
AD  - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, 
      Ontario, Canada.
FAU - Doiron, Brent
AU  - Doiron B
FAU - Maler, Leonard
AU  - Maler L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
CIN - J Neurophysiol. 2007 Apr;97(4):2577-8. PMID: 17251374
MH  - Algorithms
MH  - Animals
MH  - Data Interpretation, Statistical
MH  - Electric Fish/*physiology
MH  - Electric Stimulation
MH  - Electrophysiology
MH  - In Vitro Techniques
MH  - Lateral Line System/cytology/innervation/*physiology
MH  - Pyramidal Cells/*physiology
MH  - Reproducibility of Results
EDAT- 2007/04/06 09:00
MHDA- 2007/07/11 09:00
CRDT- 2007/04/06 09:00
PHST- 2007/04/06 09:00 [pubmed]
PHST- 2007/07/11 09:00 [medline]
PHST- 2007/04/06 09:00 [entrez]
AID - 97/4/2731 [pii]
AID - 10.1152/jn.00987.2006 [doi]
PST - ppublish
SO  - J Neurophysiol. 2007 Apr;97(4):2731-43. doi: 10.1152/jn.00987.2006.