PMID- 17409705
OWN - NLM
STAT- MEDLINE
DCOM- 20070612
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 127
IP  - 4
DP  - 2007 Apr
TI  - [Strategy to develop a new drug for treatment-resistant depression--role of 
      electroconvulsive stimuli and BDNF].
PG  - 735-42
AB  - In recent years, depression studies have focused on morphological changes 
      associated with depression. Brain-derived neurotrophic factor (BDNF) is a 
      neurotrophic factor that plays an important role in the morphological changes 
      associated with depression and the mechanisms of antidepressants. On the other 
      hand, hyperfunction of the hypothalamic-pituitary-adrenal axis has been link to 
      pathophysiology of depression. In our previous studies, ACTH-treated rats served 
      as a valuable animal model of tricyclic antidepressant-resistant depressive 
      conditions. However, few neuroanatomic studies have been done. In the present 
      study, we investigated mechanisms underling ACTH-treated rat serving an 
      imipramine treatment-resistant depression model using c-Fos as a marker. The 
      c-Fos immunohistochemical study indicated that the medial prefrontal cortex is an 
      action site of imipramine in ACTH-treated rats. Electroconvulsive therapy is 
      considered an effective treatment for treatment-resistant depression. However, 
      the mechanisms causing treatment-resistant depressive conditions are unknown. We 
      investigated the effect of repeated electrical convulsive shock (ECS)-treatment 
      using the forced swim test, a screening method for antidepressant-like activity, 
      and hippocampal BDNF protein levels in ACTH-treated rats. Findings showed that 
      repeated ECS treatment decreased the immobility time during forced swim test. 
      Furthermore, the ECS treatment also markedly increased the hippocampal BDNF 
      levels in the rat tricyclic antidepressant-resistant depression model. In 
      addition, the repeated ECS treatment showed long-lasting effects on forced swim 
      test and increased of hippocampal BDNF levels in normal rats. These findings 
      suggest that BDNF plays a key role in the antidepressant-like effect of ECS and 
      that increased BDNF may be involved in promoting the long-lasting effect.
FAU - Li, Bingjin
AU  - Li B
AD  - Department of Clinical Pharmacology and Pharmacy, Brain Science, Ehime University 
      Graduate School of Medicine, Ehime University Hospital, Japan.
FAU - Suemaru, Katsuya
AU  - Suemaru K
FAU - Kitamura, Yoshihisa
AU  - Kitamura Y
FAU - Cui, Ranji
AU  - Cui R
FAU - Gomita, Yutaka
AU  - Gomita Y
FAU - Araki, Hiroaki
AU  - Araki H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism/*physiology
MH  - Depression/etiology/*therapy
MH  - Disease Models, Animal
MH  - *Drug Design
MH  - *Electroconvulsive Therapy
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Hypothalamo-Hypophyseal System/physiology
MH  - Pituitary-Adrenal System/physiology
MH  - Rats
RF  - 43
EDAT- 2007/04/06 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/06 09:00
PHST- 2007/04/06 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/06 09:00 [entrez]
AID - JST.JSTAGE/yakushi/127.735 [pii]
AID - 10.1248/yakushi.127.735 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2007 Apr;127(4):735-42. doi: 10.1248/yakushi.127.735.