PMID- 1741033
OWN - NLM
STAT- MEDLINE
DCOM- 19920323
LR  - 20101118
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 355
IP  - 6360
DP  - 1992 Feb 6
TI  - Evidence from mosaic analysis of the masculinizing gene her-1 for cell 
      interactions in C. elegans sex determination.
PG  - 551-5
AB  - Sex in Caenorhabditis elegans is determined by a regulatory cascade of seven 
      interacting autosomal genes controlled by three X-linked genes in response to the 
      X chromosome-to-autosome (X/A) ratio. XX animals (high X/A) develop as 
      self-fertile hermaphrodites, and XO animals (low X/A) develop as males. The 
      activity of the first gene in the sex-determining cascade, her-1, is required for 
      male sexual development. XO her-1 loss-of-function mutants develop as 
      self-fertile hermaphrodites, whereas XX her-1 gain-of-function mutants develop as 
      masculinized intersexes. By genetic mosaic analysis using a fused free 
      duplication linking her-1 to a cell-autonomous marker gene, we show here that 
      her-1 expression in a sexually dimorphic cell is neither necessary nor sufficient 
      for that cell to adopt a male fate. Our results suggest that her-1 is expressed 
      in many, possibly all, cells and that its gene product can function 
      non-autonomously through cell interactions to determine male sexual development.
FAU - Hunter, C P
AU  - Hunter CP
AD  - Department of Molecular, Cellular and Developmental Biology, University of 
      Colorado, Boulder 80309-0347.
FAU - Wood, W B
AU  - Wood WB
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
SB  - IM
GS  - her-1
GS  - ncl-1
GS  - sdc-1
GS  - tra-1
MH  - Animals
MH  - Caenorhabditis/*genetics
MH  - Chromosome Mapping
MH  - Disorders of Sex Development/genetics
MH  - Dosage Compensation, Genetic
MH  - Female
MH  - Gene Expression Regulation
MH  - Male
MH  - *Mosaicism
MH  - Mutation
MH  - Pedigree
MH  - Phenotype
MH  - *Sex Determination Analysis
EDAT- 1992/02/06 00:00
MHDA- 1992/02/06 00:01
CRDT- 1992/02/06 00:00
PHST- 1992/02/06 00:00 [pubmed]
PHST- 1992/02/06 00:01 [medline]
PHST- 1992/02/06 00:00 [entrez]
AID - 10.1038/355551a0 [doi]
PST - ppublish
SO  - Nature. 1992 Feb 6;355(6360):551-5. doi: 10.1038/355551a0.