PMID- 17415848
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20130704
LR  - 20070406
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 9
IP  - 4
DP  - 2004 Oct-Dec
TI  - Survival of patients with resected pIIIa - N2 non small cell lung cancer: 
      suggestion for subclassification.
PG  - 417-22
AB  - PURPOSE: The group of completely resected stage IIIa- N2 non small cell lung 
      cancer (NSCLC) patients is considered heterogeneous in various aspects including 
      survival and pattern of recurrence. The prognostic factors still remain 
      controversial. Clinical trials dealing with multimodal strategy for N2 NSCLC are 
      being watched with keen interest, and the feasibility of this strategy is to be 
      confirmed. In the present study we attempted to clarify the role of different 
      clinicopathological factors which separate patients into high and low- risk 
      groups based on the disease-free and overall survival. PATIENTS AND METHODS: The 
      study comprised 60 consecutive patients with pathologically (p) proven N2 NSCLC 
      who had undergone complete surgical disease resection with curative intent 
      between January 1997 and September 2000. All patients had an apparently 
      resectable disease at preoperative staging and thoracotomy. Extensive mediastinal 
      lymph node dissection was performed when possible and consisted of removal of all 
      ipsilateral mediastinal lymph nodes. Patients were submitted to postoperative 
      split course adjuvant radiotherapy. Cumulative survival rates were calculated by 
      the Kaplan-Meier method. The analyzed prog- nostic factors were age, histological 
      type and grade of differentiation, clinical (c) stage, cN status and tumor size 
      and were tested for statistical significance by univariate analysis using 
      log-rank test and Willcoxon test. RESULTS: The median follow-up period was 36 
      months (range 24-72 months). Tumor size, cN status and age were significant 
      predictors of survival. Large tumor size (T3) was significantly worse predictor 
      compared to T1 (p=0.046) and cN2 status evaluated by computed tomography (CT= 
      also showed statistically significant unfavorable prognosis in comparison with 
      cN0 and cN1 (p=0.0185). Patients over 65 years had significantly worse prognosis 
      compared to those under 65 years (p=0.008). CONCLUSION: This study identified 
      stage IIIa - N2 NSCLC prognostic subgroups and suggests different therapeutic 
      approach according to the subgroup profile.
FAU - Andjelic, G
AU  - Andjelic G
AD  - Institute for Medical Research, Military Medical Academy, Beograd, Serbia and 
      Montenegro.
FAU - Stanic, V
AU  - Stanic V
FAU - Gulic, B
AU  - Gulic B
FAU - Ristanovic, A
AU  - Ristanovic A
FAU - Cvijanovic, V
AU  - Cvijanovic V
LA  - eng
PT  - Journal Article
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
EDAT- 2007/04/07 09:00
MHDA- 2007/04/07 09:01
CRDT- 2007/04/07 09:00
PHST- 2007/04/07 09:00 [pubmed]
PHST- 2007/04/07 09:01 [medline]
PHST- 2007/04/07 09:00 [entrez]
PST - ppublish
SO  - J BUON. 2004 Oct-Dec;9(4):417-22.