PMID- 17416288
OWN - NLM
STAT- MEDLINE
DCOM- 20070614
LR  - 20220225
IS  - 0188-4409 (Print)
IS  - 0188-4409 (Linking)
VI  - 38
IP  - 4
DP  - 2007 May
TI  - Acute hyperhomocysteinemia induces microvascular and macrovascular endothelial 
      dysfunction.
PG  - 411-6
AB  - BACKGROUND: Hyperhomocysteinemia (Hhcy) has been shown to induce endothelial 
      dysfunction due to a decrease in bioavailable nitric oxide (NO) by increased 
      vascular oxidant stress. This can be detected as an impairment of 
      endothelium-dependent vasodilation in conductance arteries, like brachial or 
      coronary arteries. The effect of Hhcy on endothelial function (EF) in small 
      resistance vessels that critically determine organ perfusion, however, has not 
      been studied systematically in humans. Therefore, we simultaneously determined 
      macro- and microvascular EF in 11 healthy subjects before and during acute Hhcy 
      induced by an oral methionine challenge. METHODS: Macrovascular EF was determined 
      by measuring endothelium-dependent flow-mediated vasodilation of the brachial 
      artery by vascular ultrasound and microvascular EF by measuring skin perfusion 
      during iontophoresis of acetylcholine using laser Doppler fluxmetry. RESULTS: 
      Oral methionine significantly increased homocysteine levels by about 5.1-fold. 
      Acute Hhcy leads to a significant decrease in flow-mediated vasodilation of the 
      brachial artery from 8.1 +/- 0.5% to 3.6 +/- 0.6% and to a significant decrease 
      in the ratio of acetylcholine-stimulated vs. baseline laser Doppler flow in the 
      forearm skin (from 9.2 +/- 1.0- to 7.8 +/- 1.3-fold). CONCLUSIONS: Acute Hhcy 
      impairs macro- as well as microvascular (EF) in humans.
FAU - Abahji, Thomas N
AU  - Abahji TN
AD  - Department of Vascular Medicine, University of Munich Medical Center, Munich, 
      Germany.
FAU - Nill, Lars
AU  - Nill L
FAU - Ide, Nagatoshi
AU  - Ide N
FAU - Keller, Christiane
AU  - Keller C
FAU - Hoffmann, Ulrich
AU  - Hoffmann U
FAU - Weiss, Norbert
AU  - Weiss N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Med Res
JT  - Archives of medical research
JID - 9312706
RN  - AE28F7PNPL (Methionine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/administration & dosage
MH  - Acute Disease
MH  - Adult
MH  - Brachial Artery/drug effects/*physiopathology
MH  - Endothelium, Vascular/*physiopathology
MH  - Female
MH  - Humans
MH  - Hyperhomocysteinemia/chemically induced/*physiopathology
MH  - Male
MH  - Methionine/administration & dosage
MH  - Microcirculation/drug effects/physiopathology
MH  - Skin/*blood supply
MH  - Vasodilation
EDAT- 2007/04/10 09:00
MHDA- 2007/06/15 09:00
CRDT- 2007/04/10 09:00
PHST- 2006/08/02 00:00 [received]
PHST- 2007/01/04 00:00 [accepted]
PHST- 2007/04/10 09:00 [pubmed]
PHST- 2007/06/15 09:00 [medline]
PHST- 2007/04/10 09:00 [entrez]
AID - S0188-4409(07)00032-X [pii]
AID - 10.1016/j.arcmed.2007.01.004 [doi]
PST - ppublish
SO  - Arch Med Res. 2007 May;38(4):411-6. doi: 10.1016/j.arcmed.2007.01.004.